Lack of association with TNF-α-308 promoter polymorphism in patients with vitiligo

被引:22
作者
Yazici, Ayca Cordan [1 ]
Erdal, M. Emin
Kaya, Tamer Irfan
Ikizoglu, Guliz
Savasoglu, Kaan
Camdeviren, Handan
Tursen, Umit
机构
[1] Mersin Univ, Dept Dermatol, Sch Med, TR-33079 Mersin, Turkey
[2] Mersin Univ, Dept Genet, Sch Med, TR-33079 Mersin, Turkey
[3] Mersin Univ, Dept Biostat, Sch Med, TR-33079 Mersin, Turkey
关键词
vitiligo; tumor necrosis factor-alpha; polymorphism;
D O I
10.1007/s00403-006-0664-2
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Vitiligo is an acquired depigmentary disorder of the skin, characterized by incomplete penetrance, multiple susceptibility loci and genetic heterogeneity. An immunologic hypothesis is currently advanced as a possible pathogenesis of vitiligo. The cytokines have an important role in pathogenesis of autoimmunity in which tumor necrosis factor-alpha (TNF-alpha), a paracrine inhibitor of melanocytes, is especially important. Several single-nucleotide polymorphisms (SNP) have been identified in the human TNF gene promoter. The polymorphism at position -308 (TNF-308), which involves substituting G for A and designing the AA genotype, leads to a higher rate of TNF gene transcription than the wild-type GG genotype in in vitro expression studies. It has also been linked to increased susceptibility to several chronic metabolic, degenerative, inflammatory and autoimmune diseases. Therefore, we investigated the TNF-alpha-308 SNP in patients with vitiligo. We examined 61 patients with vitiligo. Healthy age-, ethnically- and sex-matched individuals (n = 123) served as controls. Polymerase chain reaction amplification was used for analysis of the polymorphism at position -308 in promoter of TNF-alpha gene. We found that the distribution of TNF-alpha genotypes in vitiligo patients did not differ from that in control subjects (P > 0.05). Moreover, there was no association between TNF-alpha genotypes and types of vitiligo. In conclusion, we suggest that TNF-alpha-308 SNP is not a genetic risk factor for vitiligo susceptibility.
引用
收藏
页码:46 / 49
页数:4
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