Co(III)-Catalyzed [4+1] Annulation of Amides with Allenes via C-H Activation

被引：29

作者：

Boobalan, Ramadoss ^{[1
]}

Santhoshkumar, Rajagopal ^{[1
]}

Cheng, Chien-Hong ^{[1
]}

机构：

[1] Natl Tsing Hua Univ, Dept Chem, Hsinchu 30013, Taiwan

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2019年 / 361卷 / 05期

关键词：

Cobalt; Allenes; Annulation; Amides; C-H Activation; REGIOSELECTIVE INTERMOLECULAR ANNULATION; CATALYZED OXIDATIVE ANNULATION; BOND FUNCTIONALIZATION; CARBOXYLIC-ACIDS; DIRECTING GROUPS; ALKYNES; ISOQUINOLINES; SULFONAMIDES; REACTIVITY; BENZAMIDES;

D O I：

10.1002/adsc.201801335

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A Co(III)-catalyzed [4+1] annulation of amides with allenes to synthesize isoindolone and 1,5-dihydro-pyrrol-2-one derivatives is reported. A wide range of aromatic and vinylic amides react with allenes to give the corresponding annulation products in good to excellent yields. The mechanistic studies strongly support that the catalytic reaction proceeds through an amide-directed C-H activation, followed by carbocobaltation of allene, -hydride elimination, and an intramolecular 1,2-hydroamination.

引用

页码：1140 / 1145

页数：6

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