Interactions of pathogenic Neisseria with host cells.: Is it possible to assemble the puzzle?

被引：88

作者：

Nassif, X ^{[1
]}

Pujol, C ^{[1
]}

Morand, P ^{[1
]}

Eugène, E ^{[1
]}

机构：

[1] Univ Paris 05, Fac Med Necker Enfants Malad, INSERM, U411, Paris, France

来源：

MOLECULAR MICROBIOLOGY | 1999年 / 32卷 / 06期

关键词：

D O I：

10.1046/j.1365-2958.1999.01416.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Neisseria meningitidis and Neisseria gonorrhoeae are human pathogens that have to interact with mucosa and/or cellular barriers for their life cycles to progress. Even though they both give rise to dramatically different diseases, the use of in vitro models has shown that most of the mechanisms mediating cellular interactions are common to N. meningitidis and N. gonorrhoeae. This suggests that bacterial cell interactions may be essential not only for pathogenesis but also for other aspects of the bacterial life cycle that are common to both N. meningitidis and N. gonorrhoeae, This manuscript will review the most recent developments concerning the mechanisms mediating cellular interaction of pathogenic Neisseria and will then try to put them into the perspective of pathogenesis and bacterial life cycle.

引用

页码：1124 / 1132

页数：9

共 60 条

[1] The pathogenesis of gonococcal urethritis in men: Confocal and immunoelectron microscopic analysis of urethral exudates from men infected with Neisseria gonorrhoeae [J].

Apicella, MA ;

Ketterer, M ;

Lee, FKN ;

Zhou, DG ;

Rice, PA ;

Blake, MS .

JOURNAL OF INFECTIOUS DISEASES, 1996, 173 (03) :636-646

[2] Infection of epithelial cells by pathogenic neisseriae reduces the levels of multiple lysosomal constituents [J].

Ayala, P ;

Lin, L ;

Hopper, S ;

Fukuda, M ;

So, M .

INFECTION AND IMMUNITY, 1998, 66 (10) :5001-5007

[3] Mutagenesis of the Neisseria gonorrhoeae porin reduces invasion in epithelial cells and enhances phagocyte responsiveness [J].

Bauer, FJ ;

Rudel, T ;

Stein, M ;

Meyer, TF .

MOLECULAR MICROBIOLOGY, 1999, 31 (03) :903-913

[4] CD66 receptor specificity exhibited by neisserial Opa variants controlled by protein determinants in CD66 N-domains [J].

Bos, MP ;

Kuroki, M ;

Krop-Watorek, A ;

Hogan, D ;

Belland, RJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (16) :9584-9589

[5] Selection of Opa(+) Neisseria gonorrhoeae by limited availability of normal human serum [J].

Bos, MP ;

Hogan, D ;

Belland, RJ .

INFECTION AND IMMUNITY, 1997, 65 (02) :645-650

[6]

CANNON JG, 1998, 11 INT PATH NEISS C, P48

[7] Several carcinoembryonic antigens (CD66) serve as receptors for gonococcal opacity proteins [J].

Chen, T ;

Grunert, F ;

MedinaMarino, A ;

Gotschlich, EC .

JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 185 (09) :1557-1564

[8] Neisseria meningitidis producing the Opc adhesin binds epithelial cell proteoglycan receptors [J].

de Vries, FP ;

Cole, R ;

Dankert, J ;

Frosch, M ;

van Putten, JPM .

MOLECULAR MICROBIOLOGY, 1998, 27 (06) :1203-1212

[9] Vitronectin-dependent invasion of epithelial cells by Neisseria gonorrhoeae involves αV integrin receptors [J].

Dehio, M ;

Gómez-Duarte, OG ;

Dehio, C ;

Meyer, TF .

FEBS LETTERS, 1998, 424 (1-2) :84-88

[10] Vitronectin mediates internalization of Neisseria gonorrhoeae by Chinese hamster ovary cells [J].

Duensing, TD ;

vanPutten, JPM .

INFECTION AND IMMUNITY, 1997, 65 (03) :964-970

← 1 2 3 4 5 6 →