Increased Interleukin-8 in Epithelial Lining Fluid of Collapsed Lungs During One-Lung Ventilation for Thoracotomy

被引：14

作者：

Komatsu, Yoshimichi ^{[2
]}

Yamamoto, Hiroshi ^{[2
]}

Tsushima, Kenji ^{[2
]}

Furuya, Shino ^{[2
]}

Yoshikawa, Sumiko ^{[2
]}

Yasuo, Masanori ^{[2
]}

Kubo, Keishi ^{[2
]}

Yamazaki, Yoshitaka ^{[3
]}

Hasegawa, Joh ^{[4
]}

Eguchi, Takashi ^{[5
]}

Kondo, Ryuichi ^{[5
]}

Yoshida, Kazuo ^{[5
]}

Koizumi, Tomonobu ^{[1
]}

机构：

[1] Shinshu Univ Hosp, Ctr Comprehens Canc, Matsumoto, Nagano 3908621, Japan

[2] Shinshu Univ, Sch Med, Dept Internal Med 1, Matsumoto, Nagano 3908621, Japan

[3] Shinshu Univ, Sch Med, Dept Clin Lab, Matsumoto, Nagano 3908621, Japan

[4] Shinshu Univ, Sch Med, Dept Anesthesiol, Matsumoto, Nagano 3908621, Japan

[5] Shinshu Univ, Sch Med, Dept Surg 2, Matsumoto, Nagano 3908621, Japan

来源：

INFLAMMATION | 2012年 / 35卷 / 06期

基金：

日本学术振兴会;

关键词：

bronchoscopic microsampling; ARDS; permeability pulmonary edema; thoracic surgery; re-expansion pulmonary edema; RESPIRATORY-DISTRESS-SYNDROME; REEXPANSION PULMONARY-EDEMA; BRONCHOALVEOLAR LAVAGE FLUID; CARDIOPULMONARY BYPASS; RESECTION; RABBITS; INJURY; PLASMA; RISK;

D O I：

10.1007/s10753-012-9505-y

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The present study was designed to evaluate inflammatory changes in collapsed lungs during one-lung ventilation using the assistance of a bronchoscopic microsampling probe. Serial albumin and interleukin (IL)-8 concentrations in epithelial lining fluid (ELF) were measured in seven patients undergoing resection of lung tumors. The samples were taken after induction of anesthesia (baseline), 30 min after one-lung ventilation was started (point 2), just before resuming two-lung ventilation (point 3), and 30 min after two-lung ventilation was restarted (point 4). The albumin and IL-8 concentrations in ELF were significantly increased at point 2 and point 3, respectively, and remained to be high, compared to the baseline. The increase in IL-8 at point 3 was correlated with the interval of one-lung ventilation; however, none developed specific acute lung injury. These findings suggest that inflammatory changes can occur on the epithelium of a collapsed lung even in patients who underwent successful and standard thoracic surgery.

引用

页码：1844 / 1850

页数：7

共 23 条

[1]

Cheong K. F., 1999, Annals Academy of Medicine Singapore, V28, P572

[2] TYPE-III PROCOLLAGEN PEPTIDE IN THE ADULT-RESPIRATORY-DISTRESS-SYNDROME - ASSOCIATION OF INCREASED PEPTIDE LEVELS IN BRONCHOALVEOLAR LAVAGE FLUID WITH INCREASED RISK FOR DEATH [J].

CLARK, JG ;

MILBERG, JA ;

STEINBERG, KP ;

HUDSON, LD .

ANNALS OF INTERNAL MEDICINE, 1995, 122 (01) :17-23

[3] Prevalence and mortality of acute lung injury and ARDS after lung resection [J].

Dulu, Alina ;

Pastores, Stephen M. ;

Park, Bernard ;

Riedel, Elyn ;

Rusch, Valerie ;

Halpern, Neil A. .

CHEST, 2006, 130 (01) :73-78

[4] Fatal re-expansion pulmonary edema associated with increased lung IL-8 levels following high-dose chemotherapy and autologous stem cell transplant [J].

Garantziotis, S ;

Bhalla, KS ;

Long, GD ;

Vredenburgh, JJ ;

Folz, RJ .

RESPIRATION, 2002, 69 (04) :351-354

[5] Elevation of KL-6, a lung epithelial cell marker, in plasma and epithelial lining fluid in acute respiratory distress syndrome [J].

Ishizaka, A ;

Matsuda, T ;

Albertine, KH ;

Koh, H ;

Tasaka, S ;

Hasegawa, N ;

Kohno, N ;

Kotani, T ;

Morisaki, H ;

Takeda, J ;

Nakamura, M ;

Fang, XH ;

Martin, TR ;

Matthay, MA ;

Hashimoto, S .

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2004, 286 (06) :L1088-L1094

[6] New bronchoscopic microsample probe to measure the biochemical constituents in epithelial lining fluid of patients with acute respiratory distress syndrome [J].

Ishizaka, A ;

Watanabe, M ;

Yamashita, T ;

Ogawa, Y ;

Koh, H ;

Hasegawa, N ;

Nakamura, H ;

Asano, K ;

Yamaguchi, K ;

Kotani, M ;

Kotani, T ;

Morisaki, H ;

Takeda, J ;

Kobayashi, K ;

Ogawa, S .

CRITICAL CARE MEDICINE, 2001, 29 (04) :896-898

[7] NEUTROPHILS IN REEXPANSION PULMONARY-EDEMA [J].

JACKSON, RM ;

VEAL, CF ;

ALEXANDER, CB ;

BRANNEN, AL ;

FULMER, JD .

JOURNAL OF APPLIED PHYSIOLOGY, 1988, 65 (01) :228-234

[8] Inflammatory mediators in bronchoalveolar lavage fluid and plasma in leukocytopenic patients with septic shock-induced acute respiratory distress syndrome [J].

Kiehl, MG ;

Ostermann, H ;

Thomas, M ;

Muller, C ;

Cassens, U ;

Kienast, J .

CRITICAL CARE MEDICINE, 1998, 26 (07) :1194-1199

[9] Neutrophil number and interleukin-8 and elastase concentrations in bronchoalveolar lavage fluid correlate with decreased arterial oxygenation after cardiopulmonary bypass [J].

Kotani, N ;

Hashimoto, H ;

Sessler, DI ;

Muraoka, M ;

Wang, JS ;

O'Connor, MF ;

Matsuki, A .

ANESTHESIA AND ANALGESIA, 2000, 90 (05) :1046-1051

[10] Activation of a neutrophil-derived inflammatory response in the airways during cardiopulmonary bypass [J].

Kotani, Toru ;

Kotake, Yoshifumi ;

Morisaki, Hiroshi ;

Takeda, Junzo ;

Shimizu, Hideyuki ;

Ueda, Toshihiko ;

Ishizaka, Akitoshi .

ANESTHESIA AND ANALGESIA, 2006, 103 (06) :1394-1399

← 1 2 3 →