Population Pharmacokinetic Assessment of Vancomycin Dosing in the Large Pediatric Patient

被引：11

作者：

Moffett, Brady S. ^{[1
,2
]}

Ivaturi, Vijay ^{[3
]}

Morris, Jennifer ^{[1
,2
]}

Arikan, Ayse Akcan ^{[2
]}

Dutta, Ankhi ^{[2
]}

机构：

[1] Texas Childrens Hosp, Houston, TX 77030 USA

[2] Baylor Coll Med, Houston, TX 77030 USA

[3] Univ Maryland, Sch Pharm, Baltimore, MD 21201 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2019年 / 63卷 / 04期

关键词：

obesity; pediatrics; population pharmacokinetics; vancomycin; CHILDREN;

D O I：

10.1128/AAC.02359-18

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The most appropriate vancomycin dosing strategy in pediatric patients weighing >= 70 kg (weight based versus non-weight based) to achieve an area under the concentration-time curve (AUC) of >= 400 mg.liter/h and a trough concentration of <20 mg/liter is not known. Population pharmacokinetic analysis determined that dosing of vancomycin should be weight based using fat-free mass, with appropriate adjustment for kidney dysfunction.

引用

页数：6

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