Hypertension and changes in cognitive function in a Mediterranean population

被引:3
作者
Razquin, Cristina [1 ,2 ,3 ]
Menendez-Acebal, Covadonga [1 ]
Cervantes, Sebastian [4 ]
Martinez-Gonzalez, Miguel A. [1 ,2 ,3 ,5 ]
Vazquez-Ruiz, Zenaida [1 ,3 ]
Martinez-Gonzalez, Julio [6 ]
Guillen-Grima, Francisco [2 ,3 ,7 ]
Toledo, Estefania [1 ,2 ,3 ]
机构
[1] Univ Navarra, Dept Prevent Med & Publ Hlth, Pamplona, Spain
[2] Ctr Invest Biomed Red Area Fisiopatol Obesidad &, Madrid, Spain
[3] IdiSNA, Pamplona, Spain
[4] Complejo Hosp Navarra, Osasunbidea Serv Navarro Salud, Pamplona, Spain
[5] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA
[6] Hosp Reg Univ Malaga, Serv Med Interna, Malaga, Spain
[7] Clin Univ Navarra, Dept Prevent Med, Pamplona, Spain
关键词
Cognitive decline; cognitive function; hypertension; Mediterranean diet; SUN cohort; cognitive screening test; dementia; primary prevention; MODIFIED TELEPHONE INTERVIEW; VASCULAR RISK-FACTORS; TICS-M; DIET; VALIDATION; DEMENTIA; DECLINE; COHORT; ADHERENCE;
D O I
10.1080/1028415X.2020.1788773
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background:Severe cognitive decline is one of the major public health problems in developed countries. Finding modifiable risk factors could become essential to develop strategies to prevent or delay dementia progression and stop its rising incidence. Objective:Our aim was to investigate the association between hypertension and cognitive function and to assess whether better adherence to the Mediterranean diet may modify this association. Methods:A subsample of 764 participants from the 'Seguimiento Universidad de Navarra' (SUN) cohort older than 55 years was evaluated with the Spanish Telephone Interview for Cognitive Status (TICS-m) at two-time points, separated by 6 years. Multivariable-adjusted linear regression models were used to prospectively assess the association between hypertension -also according to adherence to the Mediterranean diet- and 6-y changes in cognitive function. Results:The adjusted between-group difference in the 6-year change of the TICS-m score between hypertensive participants and their non-hypertensive counterparts was -0.36 (95% CI -0.70, -0.02). This association was stronger among participants with a lower adherence to the Mediterranean diet [-0.62 (95% CI: -1.09, -0.15)] but the differences between hypertensive and non-hypertensive participants were no longer significant among participants with a higher baseline adherence to the Mediterranean diet. Conclusion:In this Mediterranean cohort, hypertension was inversely associated with cognitive function, but an attenuation of this detrimental association by a moderate/high adherence to the Mediterranean diet was suggested.
引用
收藏
页码:612 / 620
页数:9
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