Immunoglobulins in Defense, Pathogenesis, and Therapy of Fungal Diseases

被引:119
作者
Casadevall, Arturo [1 ,2 ,3 ]
Pirofski, Liise-anne [1 ,2 ,3 ]
机构
[1] Albert Einstein Coll Med, Div Infect Dis, Dept Microbiol & Immunol, Bronx, NY 10461 USA
[2] Albert Einstein Coll Med, Div Infect Dis, Dept Med, Bronx, NY 10461 USA
[3] Montefiore Med Ctr, Bronx, NY 10461 USA
关键词
CRYPTOCOCCUS-NEOFORMANS INFECTION; CAPSULAR POLYSACCHARIDE GLUCURONOXYLOMANNAN; PARACOCCIDIOIDES-BRASILIENSIS INFECTION; ANTIBODY-MEDIATED PROTECTION; CANDIDA-ALBICANS INFECTION; HYPER-IGM SYNDROME; MONOCLONAL-ANTIBODY; B-CELLS; HISTOPLASMA-CAPSULATUM; PASSIVE-IMMUNIZATION;
D O I
10.1016/j.chom.2012.04.004
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Only two decades ago antibodies to fungi were thought to have little or no role in protection against fungal diseases. However, subsequent research has provided convincing evidence that certain antibodies can modify the course of fungal infection to the benefit or detriment of the host. Hybridoma technology was the breakthrough that enabled the characterization of antibodies to fungi, illuminating some of the requirements for antibody efficacy. As discussed in this review, fungal-specific antibodies mediate protection through direct actions on fungal cells and through classical mechanisms such as phagocytosis and complement activation. Although mechanisms of antibody-mediated protection are often species-specific, numerous fungal antigens can be targeted to generate vaccines and therapeutic immunoglobulins. Furthermore, the study of antibody function against medically important fungi has provided fresh immunological insights into the complexity of humoral immunity that are likely to apply to other pathogens.
引用
收藏
页码:447 / 456
页数:10
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