The function of Fcγ receptors in dendritic cells and macrophages

被引：505

作者：

Guilliams, Martin ^{[1
,2
]}

Bruhns, Pierre ^{[3
,4
]}

Saeys, Yvan ^{[1
,2
]}

Hammad, Hamida ^{[1
,2
]}

Lambrecht, Bart N. ^{[1
,2
,5
]}

机构：

[1] VIB Inflammat Res Ctr, Immunoregulat Lab, B-9052 Ghent, Belgium

[2] Univ Ghent, Dept Resp Med, B-9000 Ghent, Belgium

[3] Inst Pasteur, Dept Immunol, Lab Anticorps Therapie & Pathol, F-75015 Paris, France

[4] Inst Natl Sante & Rech Med, U760, F-75015 Paris, France

[5] Erasmus Univ, Med Ctr, Dept Pulm Med, Rotterdam, Netherlands

来源：

NATURE REVIEWS IMMUNOLOGY | 2014年 / 14卷 / 02期

关键词：

ANTIBODY-DEPENDENT ENHANCEMENT; DENGUE HEMORRHAGIC-FEVER; IGG IMMUNE-COMPLEXES; CD8(+) T-CELLS; ANTIGEN PRESENTATION; CROSS-PRESENTATION; REGULATED EXPRESSION; CYTOPLASMIC DOMAIN; IN-VIVO; AIRWAY HYPERRESPONSIVENESS;

D O I：

10.1038/nri3582

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Dendritic cells (DCs) and macrophages use various receptors to recognize foreign antigens and to receive feedback control from adaptive immune cells. Although it was long believed that all immunoglobutin Fc receptors are universally expressed by phagocytes, recent findings indicate that only monocyte-derived DCs and macrophages express high levels of activating Fc receptors for IgG (Fc gamma Rs), whereas conventional and plasmacytoid DCs express the inhibitory Fc gamma R. In this Review, we discuss how the uptake, processing and presentation of antigens by DCs and macrophages is influenced by Fc gamma R recognition of innmunoglobulins and immune complexes in the steady state and during inflammation.

引用

页码：94 / 108

页数：15

共 152 条

[1] The MHC class I-like Fc receptor promotes humorally mediated autoimmune disease [J].

Akilesh, S ;

Petkova, S ;

Sproule, TJ ;

Shaffer, DJ ;

Christianson, GJ ;

Roopenian, D .

JOURNAL OF CLINICAL INVESTIGATION, 2004, 113 (09) :1328-1333

[2] Targeting apoptotic tumor cells to FcγR provides efficient and versatile vaccination against tumors by dendritic cells [J].

Akiyama, K ;

Ebihara, S ;

Yada, A ;

Matsumura, K ;

Aiba, S ;

Nukiwa, T ;

Takai, T .

JOURNAL OF IMMUNOLOGY, 2003, 170 (04) :1641-1648

[3] Fc receptor signaling and trafficking: a connection for antigen processing [J].

Amigorena, S ;

Bonnerot, C .

IMMUNOLOGICAL REVIEWS, 1999, 172 :279-284

[4] TYROSINE-CONTAINING MOTIF THAT TRANSDUCES CELL ACTIVATION SIGNALS ALSO DETERMINES INTERNALIZATION AND ANTIGEN PRESENTATION VIA TYPE-III RECEPTORS FOR IGG [J].

AMIGORENA, S ;

SALAMERO, J ;

DAVOUST, J ;

FRIDMAN, WH ;

BONNEROT, C .

NATURE, 1992, 358 (6384) :337-341

[5] CYTOPLASMIC DOMAIN HETEROGENEITY AND FUNCTIONS OF IGG FC-RECEPTORS IN LYMPHOCYTES-B [J].

AMIGORENA, S ;

BONNEROT, C ;

DRAKE, JR ;

CHOQUET, D ;

HUNZIKER, W ;

GUILLET, JG ;

WEBSTER, P ;

SAUTES, C ;

MELLMAN, I ;

FRIDMAN, WH .

SCIENCE, 1992, 256 (5065) :1808-1812

[6] Intravenous gammaglobulin suppresses inflammation through a novel TH2 pathway [J].

Anthony, Robert M. ;

Kobayashi, Toshihiko ;

Wermeling, Fredrik ;

Ravetch, Jeffrey V. .

NATURE, 2011, 475 (7354) :110-U133

[7] Neonatal Fc receptor for IgG (FcRn) regulates cross-presentation of IgG immune complexes by CD8-CD11b+ dendritic cells [J].

Baker, Kristi ;

Qiao, Shuo-Wang ;

Kuo, Timothy T. ;

Aveson, Victoria G. ;

Platzer, Barbara ;

Andersen, Jan-Terje ;

Sandlie, Inger ;

Chen, Zhangguo ;

de Haar, Colin ;

Lencer, Wayne I. ;

Fiebiger, Edda ;

Blumberg, Richard S. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (24) :9927-9932

[8] Signaling through FcγRIII is required for optimal T helper type (Th)2 responses and Th2-mediated airway inflammation [J].

Bandukwala, Hozefa S. ;

Clay, Bryan S. ;

Tong, Jiankun ;

Mody, Purvi D. ;

Cannon, Judy L. ;

Shilling, Rebecca A. ;

Verbeek, J. Sjef ;

Weinstock, Joel V. ;

Solway, Julian ;

Sperling, Anne I. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (08) :1875-1889

[9] Inhibition of maturation and function of dendritic cells by intravenous immunoglobulin [J].

Bayry, J ;

Lacroix-Desmazes, S ;

Carbonneil, C ;

Misra, N ;

Donkova, V ;

Pashov, A ;

Chevailler, A ;

Mouthon, L ;

Weill, B ;

Bruneval, P ;

Kazatchkine, MD ;

Kaveri, SV .

BLOOD, 2003, 101 (02) :758-765

[10] Activation of human plasmacytoid dendritic cells by TLR9 impairs FcγRII-mediated uptake of immune complexes and presentation by MHC class II [J].

Benitez-Ribas, Daniel ;

Tacken, Paul ;

Punt, Cornelis J. A. ;

de Vries, I. Jolanda M. ;

Figdor, Carl G. .

JOURNAL OF IMMUNOLOGY, 2008, 181 (08) :5219-5224

← 1 2 3 4 5 6 7 8 9 10 →