The Ventral Tegmental Area and Nucleus Accumbens as Circadian Oscillators: Implications for Drug Abuse and Substance Use Disorders

被引：28

作者：

Becker-Krail, Darius D. ^{[1
]}

Walker II, William H. ^{[1
]}

Nelson, Randy J. ^{[1
]}

机构：

[1] West Virginia Univ, Rockefeller Neurosci Inst, Dept Neurosci, Morgantown, WV 26506 USA

来源：

FRONTIERS IN PHYSIOLOGY | 2022年 / 13卷

关键词：

ventral tegmental area; nucleus accumbens; SCN; circadian rhythms; reward; oscillator; molecular clock; extra-SCN; DEPRESSION-LIKE BEHAVIOR; DISCRETE BRAIN-AREAS; CASEIN KINASE 1; REV-ERB-ALPHA; LATERAL HABENULA; PARAVENTRICULAR NUCLEUS; SUPRACHIASMATIC NUCLEUS; GENE-EXPRESSION; DISTINCT ROLES; ELECTROPHYSIOLOGICAL PROPERTIES;

D O I：

10.3389/fphys.2022.886704

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Circadian rhythms convergently evolved to allow for optimal synchronization of individuals' physiological and behavioral processes with the Earth's 24-h periodic cycling of environmental light and temperature. Whereas the suprachiasmatic nucleus (SCN) is considered the primary pacemaker of the mammalian circadian system, many extra-SCN oscillatory brain regions have been identified to not only exhibit sustainable rhythms in circadian molecular clock function, but also rhythms in overall region activity/function and mediated behaviors. In this review, we present the most recent evidence for the ventral tegmental area (VTA) and nucleus accumbens (NAc) to serve as extra-SCN oscillators and highlight studies that illustrate the functional significance of the VTA's and NAc's inherent circadian properties as they relate to reward-processing, drug abuse, and vulnerability to develop substance use disorders (SUDs).

引用

页数：17

共 249 条

[1] Neural circuits linking sleep and addiction: Animal models to understand why select individuals are more vulnerable to substance use disorders after sleep deprivation [J].

Ahrens, Allison M. ;

Ahmed, Omar J. .

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2020, 108 :435-444

[2] The orphan nuclear receptor RORα regulates circadian transcription of the mammalian core-clock Bmal1 [J].

Akashi, M ;

Takumi, T .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2005, 12 (05) :441-448

[3] mPer1 and mPer2 are essential for normal resetting of the circadian clock [J].

Albrecht, U ;

Zheng, BH ;

Larkin, D ;

Sun, ZS ;

Lee, CC .

JOURNAL OF BIOLOGICAL RHYTHMS, 2001, 16 (02) :100-104

[4] A differential response of two putative mammalian circadian regulators, mper1 and mper2, to light [J].

Albrecht, U ;

Sun, ZS ;

Eichele, G ;

Lee, CC .

CELL, 1997, 91 (07) :1055-1064

[5] Dopamine transporter function fluctuates across sleep/wake state: potential impact for addiction [J].

Alonso, I. P. ;

Pino, J. A. ;

Kortagere, S. ;

Torres, G. E. ;

Espana, R. A. .

NEUROPSYCHOPHARMACOLOGY, 2021, 46 (04) :699-708

[6] Machine Learning Helps Identify CHRONO as a Circadian Clock Component [J].

Anafi, Ron C. ;

Lee, Yool ;

Sato, Trey K. ;

Venkataraman, Anand ;

Ramanathan, Chidambaram ;

Kavakli, Ibrahim H. ;

Hughes, Michael E. ;

Baggs, Julie E. ;

Growe, Jacqueline ;

Liu, Andrew C. ;

Kim, Junhyong ;

Hogenesch, John B. .

PLOS BIOLOGY, 2014, 12 (04)

[7] Sleep abnormalities associated with alcohol, cannabis, cocaine, and opiate use: A comprehensive review [J].

Angarita G.A. ;

Emadi N. ;

Hodges S. ;

Morgan P.T. .

Addiction Science & Clinical Practice, 11 (1)

[8] Restricted feeding schedules phase shift daily rhythms of c-Fos and protein Per1 immunoreactivity in corticolimbic regions in rats [J].

Angeles-Castellanos, M. ;

Mendoza, J. ;

Escobar, C. .

NEUROSCIENCE, 2007, 144 (01) :344-355

[9] Photic Entrainment of the Circadian System [J].

Ashton, Anna ;

Foster, Russell G. ;

Jagannath, Aarti .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (02)

[10] Dopamine signalling in reward-related behaviours [J].

Baik, Ja-Hyun .

FRONTIERS IN NEURAL CIRCUITS, 2013, 7

← 1 2 3 4 5 6 7 8 9 10 →