An improved synthesis of a trifurcated Newkome-type monomer and orthogonally protected two-generation dendrons

被引:46
作者
Cardona, CM
Gawley, RE
机构
[1] Univ Miami, Dept Chem, Coral Gables, FL 33124 USA
[2] Univ Miami, NIEHS Marine & Freshwater Biomed Sci Ctr, Coral Gables, FL 33124 USA
关键词
D O I
10.1021/jo0161678
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The one-step synthesis of amino-polyether tritert-butyl ester monomer 2, by condensation of TRIS with tert-butyl acrylate, is reported. The nitrogen of the monomer can be protected with a Cbz group; subsequent removal of the tert-butyl esters with formic acid affords a triacid that is coupled to three monomers to afford an orthogonally protected two-generation, trifurcated polyether-polyamide dendron. The Cbz protecting group may be removed from the second-generation dendron without disturbing the tertbutyl esters of the periphery.
引用
收藏
页码:1411 / 1413
页数:3
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