Epidemiology and cost of herpes zoster and post-herpetic neuralgia in the United Kingdom

被引：218

作者：

Gauthier, A. ^{[1
]}

Breuer, J. ^{[2
]}

Carrington, D. ^{[3
]}

Martin, M. ^{[1
]}

Remy, V. ^{[4
]}

机构：

[1] i3 Innovus, Uxbridge UB8 1QG, Middx, England

[2] Barts & London Queen Marys Sch Med & Dent, Inst Cell & Mol Sci, Ctr Infect Dis, London, England

[3] SW Reg Lab, Hlth Protect Agcy, Bristol, Avon, England

[4] Sanofi Pasteur MSD, Hlth Econ Unit, Lyon, France

来源：

EPIDEMIOLOGY AND INFECTION | 2009年 / 137卷 / 01期

关键词：

QUALITY-OF-LIFE; RISK-FACTORS; PAIN; PREVENT; BURDEN; IMPACT; GENDER;

D O I：

10.1017/S0950268808000678

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Recent information on epidemiology and management of herpes zoster (HZ) and post-herpetic neuralgia (PHN), a painful complication of HZ, is scarce. The objective of this study was to document the burden of HZ and PHN in the United Kingdom. This retrospective analysis of the UK General Practice Research Database aimed to estimate HZ incidence and proportion of HZ patients developing PHN and to assess management costs in immunocompetent individuals aged,>= 50 years. A cohort of 27 225 HZ patients was selected.. corresponding to an incidence of 5-23/1000 person-years. Respectively 19-5 % and 13-7 % of patients developed PHN at least I and 3 months after HZ diagnosis. Mean direct cost was is an element of 103 per HZ patient and is an element of 341 and is an element of 397 per PHN episode (1- and 3-month definition respectively). Both HZ and PHN costs increased markedly with pain severity. This Study confirms that HZ and PHN are frequent and costly diseases in the United Kingdom.

引用

页码：38 / 47

页数：10

共 25 条

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