Receptor heterodimerization: a new level of cross-talk

被引：37
作者：
Barnes, PJ [1 ]
机构：
[1] Univ London Imperial Coll Sci & Technol, Natl Heart & Lung Inst, Sect Airway Dis, London SW3 6LY, England
来源：
JOURNAL OF CLINICAL INVESTIGATION | 2006年 / 116卷 / 05期
关键词：
D O I：
10.1172/JCI28535
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Most G protein-coupled receptors (GPCRs) probably exist as homodimers, but it is increasingly recognized that GPCRs may also dimerize with other types of GPCRs and that this physical interaction may affect the function of either receptor. A study in this issue of the JCI demonstrates how heterodimerization. between prostaglandin E receptors and beta(2)-adrenergic receptors (beta(2)ARs) in airway smooth muscle cells results in uncoupling Of beta(2)ARs and a diminished bronchodilator response to PAR agonists (see the related article beginning on page 1400). This illustrates what we believe to be a novel mechanism of receptor cross-talk and highlights the potential importance of GPCR heterodimerization. in diseases such as asthma and how this could lead to the development of more specific therapies in the future.
引用
收藏
页码：1210 / 1212
页数：3
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