Endocytosis and mitogenic signaling

被引：111

作者：

Di Fiore, PP

Gill, GN

机构：

[1] Ist Europeo Oncol, I-20141 Milan, Italy

[2] Univ Calif San Diego, Sch Med, La Jolla, CA 92093 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 1999年 / 11卷 / 04期

关键词：

D O I：

10.1016/S0955-0674(99)80069-6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Is there mitogenic signaling during endocytosis or is receptor internalization mainly an attenuator of signals? Recent data indicate that the answer appears to be yes to both questions. Signal transduction occurs physiologically from the cell surface and endocytosis downregulates signaling by removing receptors from the plasma membrane. In cancer, the involvement of endocytic/sorting proteins points to dysregulation of apparently unrelated pathways, which might account for an important causative role in neoplasia.

引用

页码：483 / 488

页数：6

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