Liver-Primed Memory T Cells Generated under Noninflammatory Conditions Provide Anti-infectious Immunity

被引:66
作者
Boettcher, Jan P. [1 ,2 ]
Schanz, Oliver [1 ,2 ]
Wohlleber, Dirk [1 ,2 ]
Abdullah, Zeinab [1 ,2 ]
Debey-Pascher, Svenja [3 ]
Staratschek-Jox, Andrea [3 ]
Hoechst, Bastian [1 ,2 ]
Hegenbarth, Silke [1 ,2 ]
Grell, Jessica [3 ]
Limmer, Andreas [1 ,2 ]
Atreya, Imke [6 ]
Neurath, Markus F. [6 ]
Busch, Dirk H. [4 ]
Schmitt, Edgar [7 ]
van Endert, Peter [8 ,9 ]
Kolanus, Waldemar [3 ]
Kurts, Christian [1 ,2 ]
Schultze, Joachim L. [3 ]
Diehl, Linda [1 ,2 ]
Knolle, Percy A. [1 ,2 ,5 ]
机构
[1] Univ Bonn, Inst Mol Med, D-53105 Bonn, Germany
[2] Univ Bonn, Inst Expt Immunol, D-53105 Bonn, Germany
[3] Univ Bonn, LIMES Inst, D-53105 Bonn, Germany
[4] Tech Univ Munich, Inst Microbiol & Hyg, D-81675 Munich, Germany
[5] Tech Univ Munich, Inst Mol Immunol, D-81675 Munich, Germany
[6] Univ Klinikum Erlangen, Dept Med 1, D-91054 Erlangen, Germany
[7] Johannes Gutenberg Univ Mainz, Inst Immunol, D-55122 Mainz, Germany
[8] INSERM, U1013, F-75006 Paris, France
[9] Univ Paris 05, Sorbonne Paris Cite, F-75006 Paris, France
来源
CELL REPORTS | 2013年 / 3卷 / 03期
关键词
SINUSOIDAL ENDOTHELIAL-CELLS; PERIPHERAL TOLERANCE; MOLECULAR SIGNATURE; STEADY-STATE; EFFECTOR; ANTIGEN; EXPRESSION; DIFFERENTIATION; BET; NEUROPILIN-1;
D O I
10.1016/j.celrep.2013.02.008
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Development of CD8(+) T cell (CTL) immunity or tolerance is linked to the conditions during T cell priming. Dendritic cells (DCs) matured during inflammation generate effector/memory T cells, whereas immature DCs cause T cell deletion/anergy. We identify a third outcome of T cell priming in absence of inflammation enabled by cross-presenting liver sinusoidal endothelial cells. Such priming generated memory T cells that were spared from deletion by immature DCs. Similar to central memory T cells, liver-primed T cells differentiated into effector CTLs upon antigen re-encounter on matured DCs even after prolonged absence of antigen. Their reactivation required combinatorial signaling through the TCR, CD28, and IL-12R and controlled bacterial and viral infections. Gene expression profiling identified liver-primed T cells as a distinct Neuropilin-1(+) memory population. Generation of liver-primed memory T cells may prevent pathogens that avoid DC maturation by innate immune escape from also escaping adaptive immunity through attrition of the T cell repertoire.
引用
收藏
页码:779 / 795
页数:17
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