Solvent-Specific C-N Bond Formation: Synthesis of Novel Ninhydrin-Creatinine Heterocyclic Condensation Products

被引：1

作者：

Penthala, Narsimha Reddy ^{[1
]}

Yerramreddy, Thirupathi Reddy ^{[1
]}

Parkin, Sean ^{[2
]}

Crooks, Peter A. ^{[1
]}

机构：

[1] Univ Arkansas Med Sci, Coll Pharm, Dept Pharmaceut Sci, Little Rock, AR 72205 USA

[2] Univ Kentucky, Dept Chem, Lexington, KY 40506 USA

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2013年 / 50卷

关键词：

UREAS;

D O I：

10.1002/jhet.1107

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Novel ninhydrincreatinine heterocyclic condensation products (35) were synthesized under different solvent conditions. The compound 2-(2-amino-1-methyl-4-oxo-4,5-dihydro-1H-imidazol-5-yl)-2-hydroxy-1H-ind-ene-1,3(2H)-dione (3) was formed by reacting ninhydrin (1) with creatinine (2) in the presence of sodium acetate in acetic acid. The same reactants afforded the zwitterionic compound 4 when the reaction was carried out in water, and a novel oxadiazine ring system (product 5) was generated when benzene was used as solvent.

引用

页码：E156 / E159

页数：4

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