Plasma concentrations of N-terminal brain natriuretic peptide in healthy children, adolescents, and young adults: Effect of age and gender

被引:53
作者
Mir, TS
Flato, M
Falkenberg, J
Haddad, M
Budden, R
Weil, J
Albers, S
Laer, S
机构
[1] Univ Hamburg, Klinikum Eppendorf, Herzzentrum, Klin & Poliklin Kinderkardiol, D-20246 Hamburg, Germany
[2] Univ Hamburg, Klinikum Eppendorf, Zentrum Expt Med, Inst Expt & Klin Pharmakol, D-20246 Hamburg, Germany
[3] Univ Hamburg, Klinikum Eppendorf, Zentrum Klin Theoret Med 1, Inst Klin Chem, D-20246 Hamburg, Germany
关键词
N-terminal brain natriuretic peptide; natriuretic peptides; children;
D O I
10.1007/s00246-005-1022-4
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Children with congenital heart disease need adequate diagnostic classification regarding their cardiovascular status (CVS). N-terminal brain natriuretic peptide (N-BNP) plasma concentration indicates dysfunction of the cardiovascular system and guides decisions concerning treatment and prognosis. Reference values are established for adults, with age-dependent increasing values and higher values in women. To avoid misclassification concerning the CVS, a large group of healthy children and adolescents can be used show the relationship between gender, age, and N-BNP and these can serve as reference values. N-BNP was measured in 434 healthy subjects (240 female and 194 male) with ages ranging from 0 to 32 years without any cardiovascular disease or renal or hepatic impairment. Measurements were performed with an electrochemiluminescence immunoassay from Roche Diagnostics. Mean N-BNP decreased from 12.6 fmol/ml (0-9 years; n = 79) to 9.41 fmol/ml (10-14 years; n = 154) and in adolescents from 6.1 (15-19 years; n = 99) to 4.8 fmol/ml (> 19 years; n = 102) in adults (p < 0.05). Mean N-BNP concerning gender did not differ in any age group younger than 19 years. In contrast, the adult female group had 78% higher N-BNP compared to the male group (p < 0.05). There was a significant peak in N-BNP at the age of 12-14 years. This study shows that reference values for N-BNP differed profoundly in children compared to adults and were up to 260% higher in children without any gender difference. Therefore, these reference values will help to avoid CVS misclassification in children for the biomarker N-BNP.
引用
收藏
页码:73 / 77
页数:5
相关论文
共 23 条
[1]   STUDIES OF CARDIOPULMONARY BYPASS IN CHILDREN - IMPLICATIONS FOR THE REGULATION OF BRAIN NATRIURETIC PEPTIDE [J].
ATIONU, A ;
SINGER, DRJ ;
SMITH, A ;
ELLIOTT, M ;
BURCH, M ;
CARTER, ND .
CARDIOVASCULAR RESEARCH, 1993, 27 (08) :1538-1541
[2]   The effect of estrogen replacement therapy on plasma nitric oxide and endothelin-1 levels in postmenopausal women [J].
Best, PJM ;
Berger, PB ;
Miller, VM ;
Lerman, A .
ANNALS OF INTERNAL MEDICINE, 1998, 128 (04) :285-288
[3]   Diagnostic accuracy and prognostic relevance of the measurement of cardiac natriuretic peptides: A review [J].
Clerico, A ;
Emdin, M .
CLINICAL CHEMISTRY, 2004, 50 (01) :33-50
[4]   BNP and congestive heart failure [J].
Cowie, MR ;
Mendez, GF .
PROGRESS IN CARDIOVASCULAR DISEASES, 2002, 44 (04) :293-321
[5]   B-type natriuretic peptide levels in congenital heart disease [J].
Cowley, CG ;
Bradley, JD ;
Shaddy, RE .
PEDIATRIC CARDIOLOGY, 2004, 25 (04) :336-340
[6]   The physiological and pathophysiological modulation of the endocrine function of the heart [J].
de Bold, AJ ;
Ma, KKY ;
Zhang, Y ;
de Bold, MLK ;
Bensimon, M ;
Khoshbaten, A .
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2001, 79 (08) :705-714
[7]  
DEBOLD MLK, 1999, CARDIOVASC RES, V21, P1730
[8]   Estrogen regulation of angiotensin-converting enzyme mRNA [J].
Gallagher, PE ;
Li, P ;
Lenhart, JR ;
Chappell, MC ;
Brosnihan, KB .
HYPERTENSION, 1999, 33 (01) :323-328
[9]   Immunoreactive amino-terminal pro-brain natriuretic peptide (NT-PROBNP): A new marker of cardiac impairment [J].
Hunt, PJ ;
Richards, AM ;
Nicholls, MG ;
Yandle, TG ;
Doughty, RN ;
Espiner, EA .
CLINICAL ENDOCRINOLOGY, 1997, 47 (03) :287-296
[10]  
*INT C HARM E9 EXP, 1994, STAT MED, V18, P1905