The bidirectional interaction between the sympathetic nervous system and immune mechanisms in the pathogenesis of hypertension

被引:42
作者
Carnagarin, Revathy [1 ]
Matthews, Vance [1 ]
Zaldivia, Maria T. K. [2 ,3 ]
Peter, Karlheinz [2 ,3 ]
Schlaich, Markus P. [1 ,4 ,5 ]
机构
[1] Univ Western Australia, Royal Perth Hosp Unit, Sch Med, Dobney Hypertens Ctr, Perth, WA, Australia
[2] Baker Heart & Diabet Inst, Atherothrombosis & Vasc Biol, Melbourne, Vic, Australia
[3] Monash Univ, Royal Perth Hosp, Dept Med, Perth, WA, Australia
[4] Royal Perth Hosp, Dept Cardiol, Perth, WA, Australia
[5] Royal Perth Hosp, Dept Nephrol, Perth, WA, Australia
关键词
SALT-SENSITIVE HYPERTENSION; PROTEIN-COUPLED RECEPTOR; II-INDUCED HYPERTENSION; MONOCYTE CHEMOATTRACTANT PROTEIN-1; T-LYMPHOCYTE ACTIVATION; TRIMETHYLAMINE-N-OXIDE; ANGIOTENSIN-II; BLOOD-PRESSURE; BONE-MARROW; OXIDATIVE STRESS;
D O I
10.1111/bph.14481
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Over the last few years, evidence has accumulated to suggest that hypertension is, at least in part, an immune-mediated inflammatory disorder. Many links between immunity and hypertension have been established and provide a complex framework of mechanistic interactions contributing to the rise in BP. These include immune-mediated inflammatory processes affecting regulatory brain nuclei and interactions with other mediators of cardiovascular regulation such as the sympathetic nervous system. Sympathoexcitation differentially regulates T-cells based upon activation status of the immune cell as well as the resident organ. Exogenous and endogenous triggers activate signalling pathways in innate and adaptive immune cells resulting in pro-inflammatory cytokine production and activation of T-lymphocytes in the cardiovascular and renal regions, now considered major factors in the development of essential hypertension. The inflammatory cascade is sustained and exacerbated by the immune flow via the brain-bone marrow-spleen-gastrointestinal axis and thereby further aggravating immune-mediated pathways resulting in a vicious cycle of established hypertension and target organ damage. This review summarizes the evidence and recent advances in linking immune-mediated inflammation, sympathetic activation and their bidirectional interactions with the development of hypertension. Linked Articles This article is part of a themed section on Immune Targets in Hypertension. To view the other articles in this section visit
引用
收藏
页码:1839 / 1852
页数:14
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