Synthesis and biological activity of 2′,5′-oligoadenylate trimers containing 5′-terminal 5′-amino-5′-deoxy- and 5′-amino-3′,5′-dideoxyadenosine derivatives

被引：0
|
作者：
Kvasyuk, EI
Mikhailopulo, IA
Suhadolnik, RJ
Henderson, EE
Muto, NF
Iacono, KT
Homon, J
Pfleiderer, W
机构：
[1] Univ Konstanz, Fak Chem, D-78434 Constance, Germany
[2] Temple Univ, Sch Med, Fels Inst Canc Res & Mol Biol, Philadelphia, PA 19140 USA
[3] Temple Univ, Sch Med, Dept Microbiol & Immunol, Philadelphia, PA 19140 USA
[4] Temple Univ, Sch Med, Dept Biochem, Philadelphia, PA 19140 USA
来源：
NUCLEOSIDES & NUCLEOTIDES | 1999年 / 18卷 / 6-7期
关键词：
D O I：
10.1080/07328319908044760
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Some new 2',5'-oligonucleotide trimers containing 5'-terminal 5'-amino-5'-deoxy- and 5'-amino-3',5'-dideoxyadenosine derivatives have been synthesized. Some of the trimers showed biological inhibitions, of HIV-1 reverse transcriptase (RT),HIV-1 induced syncytia formation and PCR amplification.
引用
收藏
页码：1483 / 1484
页数：2
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