Characterisation of dental pulp stem cells: A new horizon for tissue regeneration?

被引:183
作者
Kawashima, Nobuyuki [1 ]
机构
[1] Tokyo Med & Dent Univ, Grad Sch Med & Dent Sci, Oral Restitut Dept, Bunkyo Ku, Tokyo 1138549, Japan
基金
日本科学技术振兴机构;
关键词
Mesenchymal stem cells; Dental pulp; Pluripotency; Tissue regeneration; BONE MORPHOGENETIC PROTEIN-2; GROWTH-FACTOR-BETA; SIDE POPULATION CELLS; MARROW-DERIVED STEM; STEM/PROGENITOR CELLS; IN-VITRO; ODONTOGENIC DIFFERENTIATION; STROMAL CELLS; HUMAN TOOTH; ODONTOBLAST DIFFERENTIATION;
D O I
10.1016/j.archoralbio.2012.08.010
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
Stem cells possess multipotent properties that allow them to differentiate into various cells, which may be potentially useful in tissue regeneration. Stem cell populations are reported to be present in various tissues of hematopoietic, neural and mesenchymal lineages, with the presence of stem cell populations in dental pulp tissue first described more than 10 years ago. The main components of dental pulp tissue are dental pulp cells, which are mesenchymal cells derived from the neural crest.(1,2) Some of these cells demonstrate high growth potential and possess multiple differentiation properties, and have been designated dental pulp stem cells (DPSCs). These cell populations are present not only in adult pulp tissue, but also in deciduous tooth pulp and apical papilla. DPSCs isolated by different methods, such as high growth potential, using various surface markers, and high efflux of a fluorescent nuclear stain (Hoechst 33342), all show multipotency, however their surface marker expression is somewhat different from each other. In vivo studies have revealed the possibility use of DPSCs in the regeneration of various tissue. DPSCs are of dental pulp origin, and dental pulp tissue is regenerated from DPSCs. Many researchers have focused on the dentine- and bone-forming properties of DPSCs, but their neuronal and muscular differentiation capacity suggests they may have a wider clinical application. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码:1439 / 1458
页数:20
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