The importance of cytoplasm in early embryonic development

被引：3
|
作者：
Xu, KP
Rosenwaks, Z
机构：
[1] Center for Reproductive Medicine and Infertility, Cornell University Medical College, New York, NY 10021
来源：
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS | 1996年 / 13卷 / 03期
关键词：
mouse zygotes; cytoplasm; fragmentation; embryonic development;
D O I：
10.1007/BF02065945
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Purpose: A mouse model was used to evaluate the consequences of partial cytoplasm removal, which mimics the consequence of human early embryo fragmentation at the one-cell stage on embryonic development to the morula and blastocyst stages. Results: Opening the zona pellucida al the zygote stage has no detrimental effect on the number of differentiated or total cells at morula/blastocyst stage. However reduced cytoplasm significantly affects the number of inner cell mass cells, 21.7 (10% cytoplasm removed) vs 27.6 (control) and 15.1 (20% cytoplasm removed) vs 24.7 (control). Conclusions: The contribution of cytoplasm of maternal origin is critical to early embryonic development.
引用
收藏
页码：251 / 253
页数：3
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