Trophectoderm grade predicts outcomes of single-blastocyst transfers

被引：153
作者：
Hill, Micah J. [1 ,2 ]
Richter, Kevin S. [1 ]
Heitmann, Ryan J. [1 ,2 ]
Graham, James R. [1 ]
Tucker, Michael J. [1 ]
DeCherney, Alan H. [1 ,2 ]
Browne, Paulette E. [1 ]
Levens, Eric D. [1 ,2 ]
机构：
[1] Shady Grove Fertil Reprod Sci Ctr, Rockville, MD 20850 USA
[2] Eunice Kennedy Shriver NICHHD, Program Reprod & Adult Endocrinol, NIH, Bethesda, MD USA
来源：
FERTILITY AND STERILITY | 2013年 / 99卷 / 05期
基金：
美国国家卫生研究院;
关键词：
Trophectoderm; inner cell mass; embryo stage; live birth; ART; IN-VITRO FERTILIZATION; EMBRYO ASSESSMENT; PREGNANCY RATES; TRANSFER POLICY; IMPLANTATION; MORPHOLOGY; DAY-5;
D O I：
10.1016/j.fertnstert.2012.12.003
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Objective: To estimate the effect of the embryo stage, trophectoderm (TE) morphology grade, and inner cell mass (ICM) morphology grade on live birth in single-blastocyst transfers. Design: Retrospective cohort study. Setting: Large private assisted reproductive technologies (ART) practice. Patient(s): Fresh autologous ART cycles. Intervention(s): None. Main Outcome Measure(s): Live birth. Result(s): A total of 694 single-blastocyst transfers met the inclusion criteria. Univariate regression analysis showed embryo stage and TE score to be correlated with implantation and live birth. Live birth rates were 57%, 40%, and 25% for TE grades A, B, and C, respectively. There was no significant association between ICM grade and implantation or live birth. Live birth rates were 53%, 52%, and 0% for ICM grades A, B, and C respectively. Multiple logistic regression analysis showed that only patient age and TE grade were significantly associated with implantation and live birth, whereas ICM grade was not significantly associated with outcome. The TE score had the strongest correlation with live birth. Conclusion(s): TE grading, but not ICM grading, significantly correlated with implantation and live birth for single-blastocyst transfers. (Fertil Steril (R) 2013; 99:1283-9. (C) 2013 by American Society for Reproductive Medicine.)
引用
收藏
页码：1283 / +
页数：8
相关论文
共 30 条
[1]   Trophectoderm morphology: an important parameter for predicting live birth after single blastocyst transfer [J].
Ahlstrom, A. ;
Westin, C. ;
Reismer, E. ;
Wikland, M. ;
Hardarson, T. .
HUMAN REPRODUCTION, 2011, 26 (12) :3289-3296
[2]   The relationship between blastocyst morphology, chromosomal abnormality, and embryo gender [J].
Alfarawati, Samer ;
Fragouli, Elpida ;
Colls, Pere ;
Stevens, John ;
Gutierrez-Mateo, Cristina ;
Schoolcraft, William B. ;
Katz-Jaffe, Mandy G. ;
Wells, Dagan .
FERTILITY AND STERILITY, 2011, 95 (02) :520-524
[3]   Blastocyst quality affects the success of blastocyst-stage embryo transfer [J].
Balaban, B ;
Urman, B ;
Sertac, A ;
Alatas, C ;
Aksoy, S ;
Mercan, R .
FERTILITY AND STERILITY, 2000, 74 (02) :282-287
[4]   Randomized comparison of two different blastocyst grading systems [J].
Balaban, B ;
Yakin, K ;
Urman, B .
FERTILITY AND STERILITY, 2006, 85 (03) :559-563
[5]   Experience with a patient-friendly, mandatory, single-blastocyst transfer policy: the power of one [J].
Csokmay, John M. ;
Hill, Micah J. ;
Chason, Rebecca J. ;
Hennessy, Sasha ;
James, Aidita N. ;
Cohen, Jacques ;
DeCherney, Alan H. ;
Segars, James H. ;
Payson, Mark D. .
FERTILITY AND STERILITY, 2011, 96 (03) :580-584
[6]   HUMAN BLASTOCYST GRADING - AN INDICATOR OF DEVELOPMENTAL POTENTIAL [J].
DOKRAS, A ;
SARGENT, IL ;
BARLOW, DH .
HUMAN REPRODUCTION, 1993, 8 (12) :2119-2127
[7]  
Filho ES, 2012, HUM REPROD, V27, P2641
[8]   Single blastocyst transfer: a prospective randomized trial [J].
Gardner, DK ;
Surrey, E ;
Minjarez, D ;
Leitz, A ;
Stevens, J ;
Schoolcraft, WB .
FERTILITY AND STERILITY, 2004, 81 (03) :551-555
[9]   Blastocyst score affects implantation and pregnancy outcome: towards a single blastocyst transfer [J].
Gardner, DK ;
Lane, M ;
Stevens, J ;
Schlenker, T ;
Schoolcraft, WB .
FERTILITY AND STERILITY, 2000, 73 (06) :1155-1158
[10]  
Gardner DK, 1999, TOWARDS REPRODUCTIVE CERTAINTY, P378
123