Catalase is inhibited by flavonoids

被引：70
作者：
Krych, Justyna [1 ]
Gebicka, Lidia [1 ]
机构：
[1] Lodz Univ Technol TUL, Fac Chem, Inst Appl Radiat Chem, PL-93590 Lodz, Poland
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2013年 / 58卷
关键词：
Catalase; Enzyme inhibition; Flavonoids; GLUTATHIONE-S-TRANSFERASE; PHASE-II ENZYMES; IN-VITRO; ANTIOXIDANT; QUERCETIN; POLYPHENOLS; HEMOGLOBIN; METABOLISM; CHEMISTRY;
D O I：
10.1016/j.ijbiomac.2013.03.070
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Catalases, heme enzymes, which catalyze decomposition of hydrogen peroxide to water and molecular oxygen, belong to the antioxidant defense system of the cell. In this work we have shown that catalase from bovine liver is inhibited by flavonoids. The inhibition is, at least partially, due to the formation of hydrogen bonds between catalase and flavonoids. In the presence of some flavonoids the formation of unreactive catalase compound II has been detected. The most potent catalase inhibitors among the tested flavonoids have appeared myricetin, epicatechin gallate and epigallocatechin gallate. The relationship between the degree of enzyme inhibition and molecular structure of flavonoids has been analyzed. (C) 2013 Elsevier B.V. All rights reserved.
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页码：148 / 153
页数：6
相关论文
共 47 条
  • [1] Al Haji H., 2006, FREE RADICAL RES, V40, P303
  • [2] [Anonymous], PEROXIDASES CATALASE
  • [3] Quenching of quercetin quinone/quinone methides by different thiolate scavengers: Stability and reversibility of conjugate formation
    Awad, HM
    Boersma, MG
    Boeren, S
    van Bladeren, PJ
    Vervoort, J
    Rietjens, IMCM
    [J]. CHEMICAL RESEARCH IN TOXICOLOGY, 2003, 16 (07) : 822 - 831
  • [4] Structure-activity study on the quinone/quinone methide chemistry of flavonoids
    Awad, HM
    Boersma, MG
    Boeren, S
    van Bladeren, PJ
    Vervoort, J
    Rietjens, IMCM
    [J]. CHEMICAL RESEARCH IN TOXICOLOGY, 2001, 14 (04) : 398 - 408
  • [5] BEERS RF, 1952, J BIOL CHEM, V195, P133
  • [6] THE PRODUCTION OF REACTIVE OXYGEN SPECIES BY DIETARY FLAVONOLS
    CANADA, AT
    GIANNELLA, E
    NGUYEN, TD
    MASON, RP
    [J]. FREE RADICAL BIOLOGY AND MEDICINE, 1990, 9 (05) : 441 - 449
  • [7] Inhibitory effects of dietary flavonoids on purified hepatic NADH-cytochrome b5 reductase: Structure-activity relationships
    Celik, Haydar
    Kosar, Muberra
    [J]. CHEMICO-BIOLOGICAL INTERACTIONS, 2012, 197 (2-3) : 103 - 109
  • [8] HYDROPEROXIDE METABOLISM IN MAMMALIAN ORGANS
    CHANCE, B
    SIES, H
    BOVERIS, A
    [J]. PHYSIOLOGICAL REVIEWS, 1979, 59 (03) : 527 - 605
  • [9] Flavonoids - Chemistry, metabolism, cardioprotective effects, and dietary sources
    Cook, NC
    Samman, S
    [J]. JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 1996, 7 (02) : 66 - 76
  • [10] Structure-activity relationship and classification of flavonoids as inhibitors of xanthine oxidase and superoxide scavengers
    Cos, P
    Ying, L
    Calomme, M
    Hu, JP
    Cimanga, K
    Van Poel, B
    Pieters, L
    Vlietinck, AJ
    Vanden Berghe, D
    [J]. JOURNAL OF NATURAL PRODUCTS, 1998, 61 (01): : 71 - 76
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