Dual-Targeted Molecular Imaging of Cancer

被引：43

作者：

Ehlerding, Emily B. ^{[1
]}

Sun, Lingyi ^{[2
]}

Lan, Xiaoli ^{[3
]}

Zeng, Dexing ^{[2
]}

Cai, Weibo ^{[1
,4
,5
]}

机构：

[1] Univ Wisconsin, Dept Med Phys, 1530 Med Sci Ctr, Madison, WI 53706 USA

[2] Univ Pittsburgh, Dept Med, BST3,10015,3501 Fifth Ave, Pittsburgh, PA 15260 USA

[3] Huazhong Univ Sci & Technol, Union Hosp, Dept Nucl Med, Tongji Med Coll, Wuhan, Hubei, Peoples R China

[4] Univ Wisconsin, Dept Radiol, Madison, WI 53706 USA

[5] Univ Wisconsin, Carbone Canc Ctr, Madison, WI USA

来源：

JOURNAL OF NUCLEAR MEDICINE | 2018年 / 59卷 / 03期

基金：

中国国家自然科学基金; 美国国家卫生研究院;

关键词：

molecular imaging; dual-targeted; bispecific antibody fragment; cancer; positron emission tomography; BISPECIFIC ANTIBODY FRAGMENT; PROSTATE-CANCER; DRUG-DELIVERY; TUMOR TREATMENT; IN-VIVO; NANOPARTICLES; PET; INTEGRIN; PEPTIDE; HER2;

D O I：

10.2967/jnumed.117.199877

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Molecular imaging is critical to personalized and precision medicine. Although singly targeted imaging probes are making an impact both clinically and preclinically, molecular imaging strategies using bispecific probes have enabled improved visualization of cancer in recent years through synergistic targeting of two ligands. In this Focus on Molecular Imaging review, we outline how peptide-, antibody-, and nanoparticle-based platforms have affected this emerging strategy, providing examples and pointing out areas in which the greatest clinical impact may be realized.\

引用

页码：390 / 395

页数：6

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