Oxidative stress induced by fluoroquinolone enrofloxacin in zebrafish (Danio rerio) can be ameliorated after a prolonged exposure

被引：80

作者：

Sehonova, Pavia ^{[1
,2
]}

Tokanova, Nina ^{[2
]}

Hodkovicova, Nikola ^{[2
,3
]}

Kroupova, Hana Kocour ^{[4
]}

Tumova, Jitka ^{[4
]}

Blahova, Jana ^{[2
]}

Marsalek, Petr ^{[2
]}

Plhalova, Lucie ^{[2
]}

Doubkova, Veronika ^{[1
,2
]}

Dobsikova, Radka ^{[2
]}

Chloupek, Petr ^{[1
]}

Dolezalova, Petra ^{[1
]}

Faldyna, Martin ^{[3
]}

Svobodova, Zdenka ^{[2
]}

Faggio, Caterina ^{[5
]}

机构：

[1] Univ Vet & Pharmaceut Sci Brno, Fac Vet Hyg & Ecol, Dept Vet Publ Hlth & Forens Med, Brno, Czech Republic

[2] Univ Vet & Pharmaceut Sci Brno, Fac Vet Hyg & Ecol, Dept Anim Protect Welf & Behav, Brno, Czech Republic

[3] Vet Res Inst, Dept Immunol, Brno, Czech Republic

[4] Univ South Bohemia Ceske Budejovice, Fac Fisheries & Protect Waters, South Bohemian Res Ctr Aquaculture & Biodivers Hy, Vodnany, Czech Republic

[5] Univ Messina, Dept Chem Biol Pharmaceut & Environm Sci, Viale Ferdinando Stagno dAlcontres 31, I-98166 Agata Messina, Italy

来源：

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY | 2019年 / 67卷

关键词：

TBARS; Antioxidant enzymes; ctsk; opa1; pklr; EARLY-LIFE STAGES; CYPRINUS-CARPIO; TRAMADOL HYDROCHLORIDE; TOXICITY; WATER; CIPROFLOXACIN; ANTIBIOTICS; MODEL; ANTIDEPRESSANTS; NORFLOXACIN;

D O I：

10.1016/j.etap.2019.02.002

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The purpose of our experiment was to evaluate the effect of enrofloxacin on biotransformation, oxidative stress and mRNA expression of related genes in fish as a non-target organisms. Zebrafish (Danio rerio) juveniles were treated with enrofloxacin at concentrations of 5, 10 and 500 mu g/L for 14 days. A three-day-long test caused changes of catalytic activity of glutathione peroxidase and glutathione-S-transferase. Moreover, lipid peroxidation was observed at the highest concentration. No significant changes either in catalytic activity of antioxidant enzymes or elevated lipid peroxidation were observed from sampling day 7 on. mRNA expression of genes encoding antioxidant enzymes was also not affected by enrofloxacin after a 14-day exposure. This suggests the ability of D. rerio juveniles to adapt to enrofloxacin in a short time period. Moreover, enrofloxacin was not shown to affect collagen, cathepsin K, optic atrophy 1 and pyruvate kinase L/R mRNA expression in this study.

引用

页码：87 / 93

页数：7

共 48 条

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