Enterotoxigenic and nontoxigenic Bacteroides fragilis strains isolated in Brazil

被引:3
作者
Miranda, Karla R. [1 ]
Dias, Mariana F. [1 ]
Guimaraes, Priscilla L. S. [1 ]
Boente, Renata F. [1 ]
Pauer, Heidi [1 ]
Ramos, Priscila Z. [1 ]
Falcao, Lais S. [1 ]
Ferreira, Eliane de O. [1 ]
Balassiano, Ilana T. [2 ]
Ferreira, Livia Q. [1 ]
dos Santos-Filho, Joaquim [1 ]
de Paula, Geraldo R. [3 ]
Antunes, Eduardo N. F. [2 ]
Avelar, Katia E. S. [2 ]
Domingues, Regina M. C. P. [1 ]
机构
[1] Univ Fed Rio de Janeiro, Inst Microbiol Prof Paulo Goes, Dept Med Microbiol, Lab Biol Anaerobios, BR-21941900 Rio De Janeiro, Brazil
[2] Inst Oswaldo Cruz Fiocruz, Lab Zoonoses Bacterianas, Rio De Janeiro, Brazil
[3] Univ Fed Fluminense, Fac Farm, Dept Tecnol Farmaceut, Niteroi, RJ, Brazil
来源
MEMORIAS DO INSTITUTO OSWALDO CRUZ | 2008年 / 103卷 / 07期
关键词
Bacteroides fragilis toxin; enterotoxigenic Bacteroides fragilis; nontoxigenic Bacteroides fragilis;
D O I
10.1590/S0074-02762008000700018
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
The presence of enterotoxigenic Bacteroides fragilis and nontoxigenic B. fragilis (NTBF) among 109 strains isolated from 1980-2008 in Brazil were investigated by PCR. One strain, representing 0.9% of the total analyzed strains, harbored the bft gene which was identified as bft-1 isoform based on PCR-RFLP and sequencing. Forty-nine strains (44.9%) exhibited the NTBF pattern III which possesses the flanking region required for pathogenicity island acquisition in which the bft gene is codified. These data reinforce the potential of B. fragilis as an emerging enteropathogen in our country.
引用
收藏
页码:734 / 735
页数:2
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共 39 条
  • [31] Suppression of colorectal tumorigenesis by recombinant Bacteroides fragilis enterotoxin-2 in vivo
    You Lv
    Tao Ye
    Hui-Peng Wang
    Jia-Ying Zhao
    Wen-Jie Chen
    Xin Wang
    Chen-Xia Shen
    Yi-Bin Wu
    Yuan-Kun Cai
    [J]. World Journal of Gastroenterology, 2017, (04) : 603 - 613
  • [32] Detection of the Bacteroides fragilis toxin gene in sheep with and without small intestinal adenocarcinoma
    Keenan, J., I
    Aitchison, A.
    Pearson, J. F.
    Frizelle, F. A.
    Munday, J. S.
    [J]. NEW ZEALAND VETERINARY JOURNAL, 2019, 67 (06) : 329 - 332
  • [33] Suppression of colorectal tumorigenesis by recombinant Bacteroides fragilis enterotoxin-2 in vivo
    Lv, You
    Ye, Tao
    Wang, Hui-Peng
    Zhao, Jia-Ying
    Chen, Wen-Jie
    Wang, Xin
    Shen, Chen-Xia
    Wu, Yi-Bin
    Cai, Yuan-Kun
    [J]. WORLD JOURNAL OF GASTROENTEROLOGY, 2017, 23 (04) : 603 - 613
  • [34] Screening and epitope characterization of diagnostic nanobody against total and activated Bacteroides fragilis toxin
    Guo, Yucheng
    Ouyang, Zhenlin
    He, Wenbo
    Zhang, Jiaxin
    Qin, Qian
    Jiao, Min
    Muyldermans, Serge
    Zheng, Fang
    Wen, Yurong
    [J]. FRONTIERS IN IMMUNOLOGY, 2023, 14
  • [35] Bacteroides fragilis toxin stimulates intestinal epithelial cell shedding and γ-secretase-dependent E-cadherin cleavage
    Wu, Shaoguang
    Rhee, Ki-Jong
    Zhang, Ming
    Franco, Augusto
    Sears, Cynthia L.
    [J]. JOURNAL OF CELL SCIENCE, 2007, 120 (11) : 1944 - 1952
  • [36] Fragilysin, the enterotoxin from Bacteroides fragilis, enhances the serum antibody response to antigen co-administered by the intranasal route
    Vines, RR
    Perdue, SS
    Moncrief, JS
    Sentz, DR
    Barroso, LA
    Wright, RL
    Wilkins, TD
    [J]. VACCINE, 2000, 19 (06) : 655 - 660
  • [37] Bacteroides fragilis Toxin Suppresses METTL3-Mediated m6A Modification in Macrophage to Promote Inflammatory Bowel Disease
    Yan, Yuqing
    Tian, Li
    Zhao, Ying
    Xuan, Baoqin
    Xu, Xitao
    Ding, Jinmei
    Li, Weixun
    Zhou, Yi-Lu
    Zhang, Yue
    Ma, Yanru
    Ning, Lijun
    Wang, Zhenyu
    Jiang, Yi
    Zhu, Xiaoqiang
    Huang, Xiaowen
    Hu, Muni
    Shen, Nan
    Gao, Xiang
    Fang, Jing-Yuan
    Cui, Zhe
    Cao, Zhijun
    Chen, Haoyan
    Wang, Xiaoyan
    Hong, Jie
    [J]. JOURNAL OF CROHNS & COLITIS, 2025, 19 (03)
  • [38] Bacteroides fragilis Toxin Induces Intestinal Epithelial Cell Secretion of Interleukin-8 by the E-Cadherin/β-Catenin/NF-κB Dependent Pathway
    Lee, Chang-Gun
    Hwang, Soonjae
    Gwon, Sun-Yeong
    Park, Chanoh
    Jo, Minjeong
    Hong, Ju-Eun
    Rhee, Ki-Jong
    [J]. BIOMEDICINES, 2022, 10 (04)
  • [39] Bacteroides fragilis toxin rearranges the actin cytoskeleton of HT29/C1 cells without direct proteolysis of actin or decrease in F-actin content
    Saidi, RF
    Jaeger, K
    Montrose, MH
    Wu, SG
    Sears, CL
    [J]. CELL MOTILITY AND THE CYTOSKELETON, 1997, 37 (02): : 159 - 165