Organocatalytic Domino Mannich Aza-Michael Reactions towards the Stereoselective Synthesis of Highly Substituted Pipecolic Esters

被引：11
作者：
Khaliel, Souad [1 ]
Nandakumar, Mecheril Valsan [1 ]
Krautscheid, Harald [2 ]
Schneider, Christoph [1 ]
机构：
[1] Univ Leipzig, Inst Organ Chem, D-04103 Leipzig, Germany
[2] Univ Leipzig, Inst Anorgan Chem, D-04103 Leipzig, Germany
来源：
SYNLETT | 2008年 / 17期
关键词：
aza-Michael reaction; Cope rearrangement; domino reaction; Mannich reaction; organocatalysis; pipecolic ester;
D O I：
10.1055/s-0028-1083377
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Readily available chiral 7-oxo-2-enimides have been converted into highly substituted pipecolic esters in moderate yields and excellent stereocontrol through a proline-catalyzed domino Mannich aza-Michael reaction.
引用
收藏
页码：2705 / 2707
页数：3
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