Membrane Protein Structure, Function, and Dynamics: a Perspective from Experiments and Theory

被引：155

作者：

Cournia, Zoe ^{[1
]}

Allen, Toby W. ^{[2
,3
]}

Andricioaei, Ioan ^{[4
]}

Antonny, Bruno ^{[5
,6
]}

Baum, Daniel ^{[7
]}

Brannigan, Grace ^{[8
]}

Buchete, Nicolae-Viorel ^{[9
,10
]}

Deckman, Jason T. ^{[4
]}

Delemotte, Lucie ^{[11
]}

del Val, Coral ^{[12
]}

Friedman, Ran ^{[13
,14
]}

Gkeka, Paraskevi ^{[1
]}

Hege, Hans-Christian ^{[7
]}

Henin, Jerome ^{[15
,16
]}

Kasimova, Marina A. ^{[17
,18
]}

Kolocouris, Antonios ^{[19
]}

Klein, Michael L. ^{[11
]}

Khalid, Syma ^{[20
]}

Lemieux, M. Joanne ^{[21
]}

Lindow, Norbert ^{[7
]}

Roy, Mahua ^{[4
]}

Selent, Jana ^{[22
]}

Tarek, Mounir ^{[17
,23
]}

Tofoleanu, Florentina ^{[9
,10
]}

Vanni, Stefano ^{[5
,6
]}

Urban, Sinisa ^{[24
]}

Wales, David J. ^{[25
]}

Smith, Jeremy C. ^{[26
]}

Bondar, Ana-Nicoleta ^{[27
]}

机构：

[1] Acad Athens, Biomed Res Fdn, Athens 11527, Greece

[2] Univ Calif Davis, Dept Chem, Davis, CA 95616 USA

[3] RMIT Univ, Sch Appl Sci & Hlth Innovat Res Inst, Melbourne, Vic 3001, Australia

[4] Univ Calif Irvine, Dept Chem, Irvine, CA 92697 USA

[5] Univ Nice Sophia Antipolis, Inst Pharmacol Mol & Cellulaire, F-06560 Nice, France

[6] Ctr Natl Rech Sci, UMR 7275, F-06560 Nice, France

[7] Zuse Inst Berlin, Dept Visual Data Anal, D-14195 Berlin, Germany

[8] Rutgers State Univ, Dept Phys, Ctr Computat & Integrat Biol, Camden, NJ USA

[9] Univ Coll Dublin, Sch Phys, Dublin 4, Ireland

[10] Univ Coll Dublin, Complex & Adapt Syst Lab, Dublin 4, Ireland

[11] Temple Univ, Inst Computat & Mol Sci, Philadelphia, PA 19122 USA

[12] Univ Granada, Dept Artificial Intelligence, E-18071 Granada, Spain

[13] Linnaeus Univ, Dept Chem & Biomed Sci, S-39182 Kalmar, Sweden

[14] Linnaeus Univ, Ctr Biomat Chem, S-39182 Kalmar, Sweden

[15] IBPC, Lab Biochim Theor, Paris, France

[16] CNRS, Paris, France

[17] Univ Lorraine, SRSMC, UMR 7565, F-54500 Vandoeuvre Les Nancy, France

[18] Lomonosov Moscow State Univ, Moscow 119991, Russia

[19] Univ Athens, Dept Pharmaceut Chem, Fac Pharm, Athens 15771, Greece

[20] Univ Southampton, Dept Chem, Southampton SO17 1BJ, Hants, England

[21] Univ Alberta, Dept Biochem, Fac Med & Dent, Membrane Prot Dis Res Grp, Edmonton, AB T6G 2H7, Canada

[22] Univ Pompeu Fabra, IMIM Hosp Mar Med Res Inst, Dept Expt & Hlth Sci, Res Programme Biomed Informat GRIB, Barcelona 08003, Spain

[23] CNRS, SRSMC, UMR 7565, F-54500 Vandoeuvre Les Nancy, France

[24] Johns Hopkins Univ, Howard Hughes Med Inst, Dept Mol Biol & Genet, Sch Med, Baltimore, MD 21205 USA

[25] Univ Cambridge, Univ Chem Labs, Cambridge CB2 1EW, England

[26] Oak Ridge Natl Lab, Oak Ridge, TN 37831 USA

[27] Free Univ Berlin, Dept Phys, Theoret Mol Biophys, D-14195 Berlin, Germany

来源：

JOURNAL OF MEMBRANE BIOLOGY | 2015年 / 248卷 / 04期

基金：

美国国家科学基金会; 美国国家卫生研究院; 欧洲研究理事会;

关键词：

Membrane proteins; Lipids; Protein structure; Protein function; Protein dynamics; Membrane-mediated interactions; NICOTINIC ACETYLCHOLINE-RECEPTOR; FREE-ENERGY CALCULATIONS; GATED SODIUM-CHANNEL; FAMILY INTRAMEMBRANE PROTEASE; MARMORATA ELECTRIC ORGAN; M2 PROTON CHANNEL; GABA-A RECEPTOR; MOLECULAR-DYNAMICS; CRYSTAL-STRUCTURE; POTASSIUM CHANNELS;

D O I：

10.1007/s00232-015-9802-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Membrane proteins mediate processes that are fundamental for the flourishing of biological cells. Membrane-embedded transporters move ions and larger solutes across membranes; receptors mediate communication between the cell and its environment and membrane-embedded enzymes catalyze chemical reactions. Understanding these mechanisms of action requires knowledge of how the proteins couple to their fluid, hydrated lipid membrane environment. We present here current studies in computational and experimental membrane protein biophysics, and show how they address outstanding challenges in understanding the complex environmental effects on the structure, function, and dynamics of membrane proteins.

引用

页码：611 / 640

页数：30

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