Papillary Thyroid Cancer: Genetic Alterations and Molecular Biomarker Investigations

被引：281
作者：
Abdullah, Mardiaty Iryani [1 ,5 ]
Junit, Sarni Mat [1 ]
Ng, Khoon Leong [2 ]
Jayapalan, Jaime Jacqueline [3 ]
Karikalan, Barani [4 ]
Hashim, Onn Haji [1 ,3 ]
机构：
[1] Univ Malaya, Fac Med, Dept Mol Med, Kuala Lumpur 50603, Malaysia
[2] Univ Malaya, Fac Med, Dept Surg, Kuala Lumpur 50603, Malaysia
[3] Univ Malaya, Ctr Prote Res, Fac Med, Kuala Lumpur 50603, Malaysia
[4] Perdana Univ, Jalan MAEPS Perdana, Serdang 43400, Selangor, Malaysia
[5] Int Islamic Univ Malaysia, Kulliyyah Allied Hlth Sci, Dept Biomed Sci, Kuantan 25200, Pahang, Malaysia
来源：
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES | 2019年 / 16卷 / 03期
关键词：
papillary thyroid cancer; molecular alteration; genetic signature; biomarker; diagnostics; FINE-NEEDLE-ASPIRATION; BRAF V600E MUTATION; ONCOGENE REARRANGEMENTS; EXPRESSION PROFILES; CLINICAL-FEATURES; TUMOR PROGRESSION; NUCLEAR FEATURES; GROWTH-FACTOR; UP-REGULATION; CARCINOMA;
D O I：
10.7150/ijms.29935
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Papillary thyroid cancer (PTC) is the most prevalent form of malignancy among all cancers of the thyroid. It is also one of the few cancers with a rapidly increasing incidence. PTC is usually contained within the thyroid gland and generally biologically indolent. Prognosis of the cancer is excellent, with less than 2% mortality at 5 years. However, more than 25% of patients with PTC developed a recurrence during a long term follow-up. The present article provides an updated condensed overview of PTC, which focuses mainly on the molecular alterations involved and recent biomarker investigations.
引用
收藏
页码：450 / 460
页数：11
相关论文
共 50 条
[41]   Iodine nutrition and papillary thyroid cancer [J].
Zhang, Xueqi ;
Zhang, Fan ;
Li, Qiuxian ;
Feng, Chuyao ;
Teng, Weiping .
FRONTIERS IN NUTRITION, 2022, 9
[42]   Skip Metastases in Papillary Thyroid Cancer [J].
Kliseska, Elena ;
Makovac, Irena .
COLLEGIUM ANTROPOLOGICUM, 2012, 36 :59-62
[43]   Sex Differences in Papillary Thyroid Cancer [J].
Remer, Lindsay F. ;
Lee, Christina I. ;
Picado, Omar ;
Lew, John I. .
JOURNAL OF SURGICAL RESEARCH, 2022, 271 :163-170
[44]   Serum biomarkers of papillary thyroid cancer [J].
Makki, Fawaz M. ;
Taylor, S. Mark ;
Shahnavaz, Ali ;
Leslie, Andrew ;
Gallant, Jeffrey ;
Douglas, Susan ;
Teh, Evelyn ;
Trites, Jonathan ;
Bullock, Martin ;
Inglis, Karen ;
Pinto, Devanand M. ;
Hart, Robert D. .
JOURNAL OF OTOLARYNGOLOGY-HEAD & NECK SURGERY, 2013, 42
[45]   F12 as a reliable diagnostic and prognostic biomarker associated with immune infiltration in papillary thyroid cancer [J].
Luo, Jun-Hua ;
Zhang, Xiu-Xia ;
Sun, Wu-Hui .
AGING-US, 2022, 14 (08) :3687-3704
[46]   Budding uninhibited by benzimidazoles 1 might be a poor prognosis biomarker promoting the progression of papillary thyroid cancer [J].
Jiang, Wenjie ;
Yu, Yan ;
Bhandari, Adheesh ;
Hirachan, Suzita ;
Dong, Xubin ;
Huang, Xiaoli ;
Qu, Jinmiao ;
Chen, Chengze .
ENVIRONMENTAL TOXICOLOGY, 2023, 38 (09) :2047-2056
[47]   Deregulated Expression of Aurora Kinases Is Not a Prognostic Biomarker in Papillary Thyroid Cancer Patients [J].
Baldini, Enke ;
Tuccilli, Chiara ;
Prinzi, Natalie ;
Sorrenti, Salvatore ;
Falvo, Laura ;
De Vito, Corrado ;
Catania, Antonio ;
Tartaglia, Francesco ;
Mocini, Renzo ;
Coccaro, Carmela ;
Alessandrini, Stefania ;
Barollo, Susi ;
Mian, Caterina ;
Antonelli, Alessandro ;
De Antoni, Enrico ;
D'Armiento, Massimino ;
Ulisse, Salvatore .
PLOS ONE, 2015, 10 (03)
[48]   The role of matrix metalloproteinase-9 as a prognostic biomarker in papillary thyroid cancer [J].
Maryam Zarkesh ;
Azita Zadeh-Vakili ;
Mahdi Akbarzadeh ;
S. Ahmad Fanaei ;
Mehdi Hedayati ;
Fereidoun Azizi .
BMC Cancer, 18
[49]   Impact of molecular alterations of BRAF in the pathogenesis of thyroid cancer [J].
Khan, Mosin S. ;
Pandith, Arshad A. ;
Azad, Niyaz ;
ul Hussain, Mahboob ;
Masoodi, Shariq R. ;
Wani, Khursheed A. ;
Andrabi, Khurshid I. ;
Mudassar, Syed .
MUTAGENESIS, 2014, 29 (02) :131-137
[50]   A novel integrative risk index of papillary thyroid cancer progression combining genomic alterations and clinical factors [J].
Cheng, Qing ;
Li, Xuechan ;
Acharya, Chaitanya R. ;
Hyslop, Terry ;
Sosa, Julie Ann .
ONCOTARGET, 2017, 8 (10) :16690-16703
12345