Papillary Thyroid Cancer: Genetic Alterations and Molecular Biomarker Investigations

被引：281
作者：
Abdullah, Mardiaty Iryani [1 ,5 ]
Junit, Sarni Mat [1 ]
Ng, Khoon Leong [2 ]
Jayapalan, Jaime Jacqueline [3 ]
Karikalan, Barani [4 ]
Hashim, Onn Haji [1 ,3 ]
机构：
[1] Univ Malaya, Fac Med, Dept Mol Med, Kuala Lumpur 50603, Malaysia
[2] Univ Malaya, Fac Med, Dept Surg, Kuala Lumpur 50603, Malaysia
[3] Univ Malaya, Ctr Prote Res, Fac Med, Kuala Lumpur 50603, Malaysia
[4] Perdana Univ, Jalan MAEPS Perdana, Serdang 43400, Selangor, Malaysia
[5] Int Islamic Univ Malaysia, Kulliyyah Allied Hlth Sci, Dept Biomed Sci, Kuantan 25200, Pahang, Malaysia
来源：
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES | 2019年 / 16卷 / 03期
关键词：
papillary thyroid cancer; molecular alteration; genetic signature; biomarker; diagnostics; FINE-NEEDLE-ASPIRATION; BRAF V600E MUTATION; ONCOGENE REARRANGEMENTS; EXPRESSION PROFILES; CLINICAL-FEATURES; TUMOR PROGRESSION; NUCLEAR FEATURES; GROWTH-FACTOR; UP-REGULATION; CARCINOMA;
D O I：
10.7150/ijms.29935
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Papillary thyroid cancer (PTC) is the most prevalent form of malignancy among all cancers of the thyroid. It is also one of the few cancers with a rapidly increasing incidence. PTC is usually contained within the thyroid gland and generally biologically indolent. Prognosis of the cancer is excellent, with less than 2% mortality at 5 years. However, more than 25% of patients with PTC developed a recurrence during a long term follow-up. The present article provides an updated condensed overview of PTC, which focuses mainly on the molecular alterations involved and recent biomarker investigations.
引用
收藏
页码：450 / 460
页数：11
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