20S ways to apoptosis

被引：2

作者：

McConkey, David J. ^{[1
,2
]}

机构：

[1] MD Anderson Canc Ctr, Dept Urol, Houston, TX 77030 USA

[2] MD Anderson Canc Ctr, Dept Canc Biol, Houston, TX 77030 USA

来源：

NATURE CHEMICAL BIOLOGY | 2008年 / 4卷 / 09期

关键词：

D O I：

10.1038/nchembio0908-528

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chemical inhibitors of the proteasome have received substantial attention owing to the success of bortezomib in the treatment of multiple myeloma. A recent whole-cell screen identified the proteasome inhibitor argyrin A and suggests a new role for p27(Kip-1) in regulating apoptosis.

引用

页码：528 / 529

页数：3