A three-component, one-pot synthesis of 1,8-naphthyridine and isoxazole derivatives and computational elucidation of the mechanism

被引：4

作者：

Guleli, Muge ^{[1
]}

Erdem, Safiye S. ^{[2
]}

Ocal, Nuket ^{[1
]}

Erden, Ihsan ^{[3
]}

Sari, Ozlem ^{[4
]}

机构：

[1] Yildiz Tech Univ, Dept Chem, Fac Arts & Sci, Davutpasa Campus, TR-34220 Esenler, Turkey

[2] Marmara Univ, Dept Chem, Fac Arts & Sci, TR-34722 Istanbul, Turkey

[3] San Francisco State Univ, Dept Chem & Biochem, 1600 Holloway Ave, San Francisco, CA 94132 USA

[4] Kirsehir Ahi Evran Univ, Dept Chem, TR-40100 Kirsehir, Turkey

来源：

RESEARCH ON CHEMICAL INTERMEDIATES | 2019年 / 45卷 / 04期

基金：

美国国家卫生研究院;

关键词：

Isoxazoles; 1,8-Naphthyridines; Catalyst; Conjugated heterocycles; Computational studies; PATH; AROMATICITY; CONTINUUM; OXIDATION; KINETICS; ANALOGS;

D O I：

10.1007/s11164-018-03721-z

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient and general method for the synthesis of substituted 3,4-dimethylisoxazolo[5,4-b]pyridine-5-carboxamide and benzo[b][1,8]naphthyridine-3-carboxamide derivatives by using 2,2,6-trimethyl-4H-1,3-dioxin-4-one, benzyl amine, aromatic aldehydes, 2-aminoquinoline, or 5-amino-3-methylisoxazole in the presence of a catalytic amount of p-toluenesulfonic acid or iodine is described. The formation of the products was investigated and the results obtained were also supported by theoretical calculations.

引用

页码：2119 / 2134

页数：16

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