Circulating Heat Shock Protein 60 Levels Are Elevated in HIV Patients and Are Reduced by Anti-Retroviral Therapy

被引：13

作者：

Anraku, Itaru ^{[1
]}

Rajasuriar, Reena ^{[2
,3
]}

Dobbin, Caroline ^{[4
]}

Brown, Richard ^{[4
]}

Lewin, Sharon R. ^{[2
,5
,6
]}

Suhrbier, Andreas ^{[1
,7
]}

机构：

[1] Queensland Inst Med Res, Brisbane, Qld 4006, Australia

[2] Alfred Hosp, Dept Infect Dis, Melbourne, Vic, Australia

[3] Univ Malaya, Fac Med, Kuala Lumpur, Malaysia

[4] CBio Ltd, Brisbane, Qld, Australia

[5] Monash Univ, Melbourne, Vic 3004, Australia

[6] Burnet Inst, Ctr Virol, Melbourne, Vic, Australia

[7] Griffith Univ, Sch Biomol & Phys Sci, Brisbane, Qld 4111, Australia

来源：

PLOS ONE | 2012年 / 7卷 / 09期

基金：

澳大利亚研究理事会;

关键词：

SOLUBLE HEAT-SHOCK-PROTEIN-60; MICROBIAL TRANSLOCATION; CARDIOVASCULAR-DISEASE; SERUM; HSP60; RISK; LIPOPOLYSACCHARIDE; ATHEROSCLEROSIS; INFECTION; RESPONSES;

D O I：

10.1371/journal.pone.0045291

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Circulating heat shock protein 60 (Hsp60) and heat shock protein 10 (Hsp10) have been associated with pro-and anti-inflammatory activity, respectively. To determine whether these heat shock proteins might be associated with the immune activation seen in HIV-infected patients, the plasma levels of Hsp60 and Hsp10 were determined in a cohort of 20 HIV-infected patients before and after effective combination anti-retroviral therapy (cART). We show for the first time that circulating Hsp60 levels are elevated in HIV-infected patients, with levels significantly reduced after cART, but still higher than those in HIV-negative individuals. Hsp60 levels correlated significantly with viral load, CD4 counts, and circulating soluble CD14 and lipopolysaccharide levels. No differences or correlations were seen for Hsp10 levels. Elevated circulating Hsp60 may contribute to the immune dysfunction and non-AIDS clinical events seen in HIV-infected patients.

引用

页数：4

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