Bioorthogonal Copper-Free Click Chemistry In Vivo for Tumor-Targeted Delivery of Nanoparticles

被引：232
|
作者：
Koo, Heebeom [1 ]
Lee, Sangmin [2 ]
Na, Jin Hee [2 ]
Kim, Sun Hwa [1 ]
Hahn, Sei Kwang [3 ]
Choi, Kuiwon [1 ]
Kwon, Ick Chan [1 ]
Jeong, Seo Young [2 ]
Kim, Kwangmeyung [1 ]
机构：
[1] Ko Rea Inst Sci & Technol, Biomed Res Inst, Ctr Theragnosis, Seoul 136791, South Korea
[2] Kyung Hee Univ, Dept Life & Nanopharmaceut Sci, Seoul, South Korea
[3] Pohang Univ Sci & Technol, Dept Mat Sci & Engn, Pohang, South Korea
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 47期
关键词：
click chemistry; drug delivery; metabolic glycoengineering; nanoparticle; tumor targeting; LIVING ANIMALS; CYCLOADDITIONS; PROTEINS; GLYCANS; SYSTEMS; CELLS;
D O I：
10.1002/anie.201206703
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Right on target: An invivo tumor-targeting strategy using nanoparticles has been developed. An unnatural sialic acid (green, see scheme) with azide groups is artificially generated on the target site by metabolic glycoengineering. These groups then effectively enhance the accumulation of nanoparticles in the target tumor site by an invivo bioorthogonal copper-free click reaction. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：11836 / 11840
页数：5
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