Bacterial Adhesion Forces with Substratum Surfaces and the Susceptibility of Biofilms to Antibiotics

被引:44
|
作者
Muszanska, Agnieszka K. [1 ,2 ]
Nejadnik, M. Reza [1 ,2 ]
Chen, Yun [1 ,2 ]
van den Heuvel, Edwin R. [3 ]
Busscher, Henk J. [1 ,2 ]
van der Mei, Henny C. [1 ,2 ]
Norde, Willem [1 ,2 ]
机构
[1] Univ Med Ctr Groningen, WJ Kolff Inst, Dept Biomed Engn, NL-9713 AV Groningen, Netherlands
[2] Univ Groningen, Groningen, Netherlands
[3] Univ Med Ctr Groningen, Dept Epidemiol, NL-9713 AV Groningen, Netherlands
关键词
PSEUDOMONAS-AERUGINOSA; RESISTANCE;
D O I
10.1128/AAC.00431-12
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Biofilms causing biomaterial-associated infection resist antibiotic treatment and usually necessitate the replacement of infected implants. Here we relate bacterial adhesion forces and the antibiotic susceptibility of biofilms on uncoated and polymer brush-coated silicone rubber. Nine strains of Staphylococcus aureus, Staphylococcus epidermidis, and Pseudomonas aeruginosa adhered more weakly to brush-coated silicone rubber (-0.05 +/- 0.03 to -0.51 +/- 0.62 nN) than to uncoated silicone rubber (-1.05 +/- 0.46 to -5.1 +/- 1.3 nN). Biofilms of weakly adhering organisms on polymer brush coatings remained in a planktonic state, susceptible to gentamicin, unlike biofilms formed on uncoated silicone rubber.
引用
收藏
页码:4961 / 4964
页数:4
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