Bacterial Adhesion Forces with Substratum Surfaces and the Susceptibility of Biofilms to Antibiotics

被引：45

作者：

Muszanska, Agnieszka K. ^{[1
,2
]}

Nejadnik, M. Reza ^{[1
,2
]}

Chen, Yun ^{[1
,2
]}

van den Heuvel, Edwin R. ^{[3
]}

Busscher, Henk J. ^{[1
,2
]}

van der Mei, Henny C. ^{[1
,2
]}

Norde, Willem ^{[1
,2
]}

机构：

[1] Univ Med Ctr Groningen, WJ Kolff Inst, Dept Biomed Engn, NL-9713 AV Groningen, Netherlands

[2] Univ Groningen, Groningen, Netherlands

[3] Univ Med Ctr Groningen, Dept Epidemiol, NL-9713 AV Groningen, Netherlands

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2012年 / 56卷 / 09期

关键词：

PSEUDOMONAS-AERUGINOSA; RESISTANCE;

D O I：

10.1128/AAC.00431-12

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Biofilms causing biomaterial-associated infection resist antibiotic treatment and usually necessitate the replacement of infected implants. Here we relate bacterial adhesion forces and the antibiotic susceptibility of biofilms on uncoated and polymer brush-coated silicone rubber. Nine strains of Staphylococcus aureus, Staphylococcus epidermidis, and Pseudomonas aeruginosa adhered more weakly to brush-coated silicone rubber (-0.05 +/- 0.03 to -0.51 +/- 0.62 nN) than to uncoated silicone rubber (-1.05 +/- 0.46 to -5.1 +/- 1.3 nN). Biofilms of weakly adhering organisms on polymer brush coatings remained in a planktonic state, susceptible to gentamicin, unlike biofilms formed on uncoated silicone rubber.

引用

页码：4961 / 4964

页数：4

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