Zizimauritic acids A-C, three novel nortriterpenes from Ziziphus mauritiana

被引：21

作者：

Ji, Chang-Jiu ^{[1
,2
]}

Zeng, Guang-Zhi ^{[1
]}

Han, Jing ^{[1
,2
]}

He, Wen-Jun ^{[1
]}

Zhang, Yu-Mei ^{[1
]}

Tan, Ning-Hua ^{[1
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Yunnan, Peoples R China

[2] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2012年 / 22卷 / 20期

基金：

中国国家自然科学基金;

关键词：

Ziziphus mauritiana; Nortriterpene; Zizimauritic acids A-C; Cytotoxicity; Antibacterial activity; CYCLOPEPTIDE ALKALOIDS; LEAVES; TRITERPENE;

D O I：

10.1016/j.bmcl.2012.08.074

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Zizimauritic acids A-C (1-3), three novel nortriterpenes with a unique A-nor-E-seco spiro-lactone ceanothane-type triterpene skeleton, together with 3 known triterpenes ceanothenic acid (4), betulinic acid (5), and ceanothic acid (6), were isolated from the roots of Ziziphus mauritiana. Compounds 1-4 showed cytotoxicities with the IC50 values ranging from 5.05 to 11.94 mu g/ml, and compounds 1 and 3 showed an inhibitory effect on the growth of Staphylococcus aureus with the IC50 values 2.17 and 12.79 mu g/ml. A plausible biosynthetic pathway of compounds 1-3 was proposed. (c) 2012 Elsevier Ltd. All rights reserved.

引用

页码：6377 / 6380

页数：4

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