Utility of Screening for Chronic Granulomatous Disease in Patients with Inflammatory Bowel Disease

被引：14

作者：

Jaggi, Preeti ^{[1
]}

Scherzer, Rebecca ^{[2
]}

Knieper, Rose ^{[1
]}

Mousa, Hayat ^{[3
]}

Prasad, Vinay ^{[4
]}

机构：

[1] Nationwide Childrens Hosp, Sect Infect Dis & Immunol, Columbus, OH 43205 USA

[2] Ohio State Univ, Coll Med, Dept Pediat, Columbus, OH 43210 USA

[3] Nationwide Childrens Hosp, Gastroenterol Sect, Columbus, OH USA

[4] Nationwide Childrens Hosp, Sect Pathol, Columbus, OH USA

来源：

JOURNAL OF CLINICAL IMMUNOLOGY | 2012年 / 32卷 / 01期

关键词：

Chronic granulomatous disease; inflammatory bowel disease; colitis; ADULT WOMAN; CARRIERS; COLITIS;

D O I：

10.1007/s10875-011-9608-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Chronic granulomatous disease (CGD), a genetically heterogeneous primary X-linked or autosomal recessive immunodeficiency, can manifest with gastrointestinal symptoms, including colitis or Crohn's disease. The frequency of CGD carriers among those with chronic colitis/inflammatory bowel disease is unknown. We underwent a pilot study examining the value of prospectively screening patients with chronic colitis/inflammatory bowel disease (IBD) for either CGD or the carrier state of CGD. No carriers of CGD or patients with CGD were detected among 120 patients. Three patients had inconclusive results and the assay was normal on repeat testing. We conclude that routine screening for CGD was not instructive in this cohort of chronic colitis or IBD patients.

引用

页码：78 / 81

页数：4

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