No Adaptation of the Prion Strain in a Heterozygous Case of Variant Creutzfeldt-Jakob Disease

被引：4

作者：

Boyle, Aileen ^{[1
]}

Plinston, Chris ^{[1
]}

Laing, Fraser ^{[1
]}

Mackenzie, Graeme ^{[2
]}

Will, Robert G. ^{[3
]}

Manson, Jean C. ^{[3
]}

Diack, Abigail B. ^{[1
]}

机构：

[1] Roslin Inst, Easter Bush, Scotland

[2] Western Gen Hosp, Edinburgh, Midlothian, Scotland

[3] Univ Edinburgh, Edinburgh, Midlothian, Scotland

来源：

EMERGING INFECTIOUS DISEASES | 2020年 / 26卷 / 06期

基金：

英国生物技术与生命科学研究理事会; 英国医学研究理事会;

关键词：

TRANSMISSION; SCRAPIE; PATIENT; CJD;

D O I：

10.3201/eid2606.191116

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We investigated a clinical case of variant Creutzfeldt-Jakob Disease in a person heterozygous for methionine/valine at codon 129 of the prion protein gene and identified the same strain properties in variant Creutzfeldt-Jakob disease in methionine homozygous persons and in bovine spongiform encephalopathy. These results indicate no adaptation of the agent in a different genetic background.

引用

收藏

页码：1300 / 1303

页数：4

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