LMP1 structure and signal transduction

被引：200

作者：

Eliopoulos, AG ^{[1
]}

Young, LS ^{[1
]}

机构：

[1] Univ Birmingham, Sch Med, CRC, Inst Canc Studies, Birmingham B15 2TA, W Midlands, England

来源：

SEMINARS IN CANCER BIOLOGY | 2001年 / 11卷 / 06期

基金：

英国医学研究理事会;

关键词：

EBV; CD40; LMP1; signalling;

D O I：

10.1006/scbi.2001.0410

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The oncogenic Epstein-Barr virus (EBV)-encoded latent membrane protein I (LMP1) has structural features and functions reminiscent of a constitutively active TNF family receptor LMP1 aggregates at the plasma membrane and initiates the activation of signalling pathways, such as NF-kappaB, the mitogen-activated protein kinases JNK and p38, the small GTPase Cdc42 and the JAK/STAT cascade. The constitutive engagement of these signals and the characteristic molecular interactions that regulate them provide the basis for the molecular explanation of the transforming properties of this key EBV protein.

引用

页码：435 / 444

页数：10

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