In vivo potential antidiabetic activity of a novel zinc coordination compound based on 3-carboxy-pyrazole

被引：33

作者：

Lopez-Viseras, Marta E. ^{[1
]}

Fernandez, Belen ^{[2
]}

Hilfiker, Sabine ^{[2
]}

Gonzalez, Cristina Sanchez ^{[3
,4
]}

Gonzalez, Juan Llopis ^{[3
,4
]}

Calahorro, Antonio J. ^{[1
]}

Colacio, Enrique ^{[1
]}

Rodriguez-Dieguez, Antonio ^{[1
]}

机构：

[1] Univ Granada, Dept Quim Inorgan, E-18071 Granada, Spain

[2] CSIC, Inst Parasitol & Biomed Lopez Neyra, Granada, Spain

[3] Univ Granada, Inst Nutr & Tecnol Alimentos, E-18071 Granada, Spain

[4] Univ Granada, Dept Fisiol, E-18071 Granada, Spain

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2014年 / 131卷

关键词：

Coordination compound; Antidiabetic activity; in vitro toxicity; MAGNETIC-PROPERTIES; COMPLEXES; SULFATE; GLUCOSE; TISSUES; LIGAND; MICE;

D O I：

10.1016/j.jinorgbio.2013.10.019

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A novel Zn mononuclear complex with 3-carboxy-pyrazole ligand has been prepared using conventional routes and characterized by X-ray diffraction. The structure consists of discrete neutral [Zn(C6H3N2O2)(2)(H2O)(2)] molecules held together by hydrogen interactions. This compound exhibits a potential in vivo antidiabetic activity and the in vitro toxicity can be considered negligible. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：64 / 67

页数：4

共 14 条

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