Value of post-therapy 177Lu-PSMA images for accurate interpretation of therapy response with 68Ga-PSMA PET/CT

被引：1

作者：

Tuncel, M. ^{[1
]}

Telli, T. ^{[1
]}

机构：

[1] Hacettepe Univ, Fac Med, Dept Nucl Med, Ankara, Turkey

来源：

REVISTA ESPANOLA DE MEDICINA NUCLEAR E IMAGEN MOLECULAR | 2018年 / 37卷 / 02期

关键词：

Ga-68-PSMA; Lu-177-PSMA; Tumor sink effect; Therapeutic response; PROSTATE-CANCER; GUIDELINES; ANTIGEN;

D O I：

10.1016/j.remn.2017.05.004

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

A 54-year-old man with progressive prostate cancer underwent a Ga-68-PSMA PET/CT, which showed lymph node and bone metastases. After 2-cycles of Lu-177-PSMA therapy, the repeated Ga-68-PSMA PET/CT showed decreased radiotracer uptake in lymph node and bones metastases, but there were new lesions which may be compatible with progression or tumour sink-effect. A review of Lu-177-PSMA-therapy images revealed that new lesions in the second PET/CT were the metastatic lesions that progressed after the first PET/CT, and subsequently showed a good response. The patient received additional cycles of Lu-177-PSMA therapy, and the disease regressed further, with a PSA of 0.06 ng/ml. Response evaluation of new therapeutic diagnostics (theranostic) agents needs a review of not only diagnostic PET/CT images, but also post-therapy images and laboratory results. (C) 2017 Elsevier Espana, S.L.U. y SEMNIM. All rights reserved.

引用

页码：114 / 117

页数：4

共 10 条

[1] The tumour sink effect on the biodistribution of 68Ga-DOTA-octreotate: implications for peptide receptor radionuclide therapy [J].

Beauregard, Jean-Mathieu ;

Hofman, Michael S. ;

Kong, Grace ;

Hicks, Rodney J. .

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2012, 39 (01) :50-56

[2] Eligibility and response guidelines for phase II clinical trials in androgen-independent prostate cancer: Recommendations from the prostate-specific antigen working group [J].

Bubley, GJ ;

Carducci, M ;

Dahut, W ;

Dawson, N ;

Daliani, D ;

Eisenberger, M ;

Figg, WD ;

Freidlin, B ;

Halabi, S ;

Hudes, G ;

Hussain, M ;

Kaplan, R ;

Myers, C ;

Oh, W ;

Petrylak, DP ;

Reed, E ;

Roth, B ;

Sartor, O ;

Scher, H ;

Simons, J ;

Sinibaldi, V ;

Small, EJ ;

Smith, MR ;

Trump, DL ;

Vollmer, R ;

Wilding, G .

JOURNAL OF CLINICAL ONCOLOGY, 1999, 17 (11) :3461-3467

[3] 99MTc bone scintigraphy superscans:: a review [J].

Buckley, Orla ;

O'Keeffe, Sylvia ;

Geoghegan, Tony ;

Lyburn, Ian D. ;

Munk, Peter L. ;

Worsley, Dan ;

Torreggiani, William C. .

NUCLEAR MEDICINE COMMUNICATIONS, 2007, 28 (07) :521-527

[4] 68Ga-PSMA PET/CT: Joint EANM and SNMMI procedure guideline for prostate cancer imaging: version 1.0 [J].

Fendler, Wolfgang P. ;

Eiber, Matthias ;

Beheshti, Mohsen ;

Bomanji, Jamshed ;

Ceci, Francesco ;

Cho, Steven ;

Giesel, Frederik ;

Haberkorn, Uwe ;

Hope, Thomas A. ;

Kopka, Klaus ;

Krause, Bernd J. ;

Mottaghy, Felix M. ;

Schoder, Heiko ;

Sunderland, John ;

Wan, Simon ;

Wester, Hans-Juergen ;

Fanti, Stefano ;

Herrmann, Ken .

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2017, 44 (06) :1014-1024

[5] 123I-MIP-1072, a Small-Molecule Inhibitor of Prostate-Specific Membrane Antigen, Is Effective at Monitoring Tumor Response to Taxane Therapy [J].

Hillier, Shawn M. ;

Kern, Ashley M. ;

Maresca, Kevin P. ;

Marquis, John C. ;

Eckelman, William C. ;

Joyal, John L. ;

Babich, John W. .

JOURNAL OF NUCLEAR MEDICINE, 2011, 52 (07) :1087-1093

[6] 68Ga-PSMA-11 PET Imaging of Response to Androgen Receptor Inhibition: First Human Experience [J].

Hope, Thomas A. ;

Truillet, Charles ;

Ehman, Eric C. ;

Afshar-Oromieh, Ali ;

Aggarwal, Rahul ;

Ryan, Charles J. ;

Carroll, Peter R. ;

Small, Eric J. ;

Evans, Michael J. .

JOURNAL OF NUCLEAR MEDICINE, 2017, 58 (01) :81-84

[7] Prostate Cancer, Version 1.2016 Featured Updates to the NCCN Guidelines [J].

Mohler, James L. ;

Armstrong, Andrew J. ;

Bahnson, Robert R. ;

D'Amico, Anthony Victor ;

Davis, Brian J. ;

Eastham, James A. ;

Enke, Charles A. ;

Farrington, Thomas A. ;

Higano, Celestia S. ;

Horwitz, Eric M. ;

Hurwitz, Michael ;

Kane, Christopher J. ;

Kawachi, Mark H. ;

Kuettel, Michael ;

Lee, Richard J. ;

Meeks, Joshua J. ;

Penson, David F. ;

Plimack, Elizabeth R. ;

Pow-Sang, Julio M. ;

Raben, David ;

Richey, Sylvia ;

Roach, Mack, III ;

Rosenfeld, Stan ;

Schaeffer, Edward ;

Skolarus, Ted A. ;

Small, Eric J. ;

Sonpavde, Guru ;

Srinivas, Sandy ;

Strope, Seth A. ;

Tward, Jonathan ;

Shead, Dorothy A. ;

Freedman-Cass, Deborah A. .

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK, 2016, 14 (01) :19-30

[8] German Multicenter Study Investigating 177Lu-PSMA-617 Radioligand Therapy in Advanced Prostate Cancer Patients [J].

Rahbar, Kambiz ;

Ahmadzadehfar, Hojjat ;

Kratochwil, Clemens ;

Haberkorn, Uwe ;

Schaefers, Michael ;

Essler, Markus ;

Baum, Richard P. ;

Kulkarni, Harshad R. ;

Schmidt, Matthias ;

Drzezga, Alexander ;

Bartenstein, Peter ;

Pfestroff, Andreas ;

Luster, Markus ;

Luetzen, Ulf ;

Marx, Marlies ;

Prasad, Vikas ;

Brenner, Winfried ;

Heinzel, Alexander ;

Mottaghy, Felix M. ;

Ruf, Juri ;

Meyer, Philipp Tobias ;

Heuschkel, Martin ;

Eveslage, Maria ;

Boegemann, Martin ;

Fendler, Wolfgang Peter ;

Krause, Bernd Joachim .

JOURNAL OF NUCLEAR MEDICINE, 2017, 58 (01) :85-90

[9] Advances in the management of castration resistant prostate cancer [J].

Ritch, Chad R. ;

Cookson, Michael S. .

BMJ-BRITISH MEDICAL JOURNAL, 2016, 355

[10] Demonstration of Response to Androgen Deprivation Therapy by 68Ga-PSMA PET/CT [J].

Soydal, Cigdem ;

Ozkan, Elgin ;

Kaya, Bektas ;

Kucuk, Ozlem Nuriye .

CLINICAL NUCLEAR MEDICINE, 2016, 41 (10) :794-796

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