Nicotine dependence produces hyperalgesia: Role of corticotropin-releasing factor-1 receptors (CRF1Rs) in the central amygdala (CeA)

被引:43
作者
Baiamonte, Brandon A. [1 ]
Valenza, Marta [2 ,3 ]
Roltsch, Emily A. [1 ]
Whitaker, Annie M. [1 ]
Baynes, Brittni B. [1 ]
Sabino, Valentina [2 ,3 ]
Gilpin, Nicholas W. [1 ,4 ]
机构
[1] Louisiana State Univ, Hlth Sci Ctr, Dept Physiol, New Orleans, LA USA
[2] Boston Univ, Sch Med, Dept Pharmacol, Lab Addict Disorders, Boston, MA 02118 USA
[3] Boston Univ, Sch Med, Dept Psychiat, Boston, MA 02118 USA
[4] Louisiana State Univ, Hlth Sci Ctr, Neurosci Ctr Excellence, New Orleans, LA USA
关键词
Nicotine dependence; CRF1; receptor; R121919; Hargreaves; Withdrawal; ANXIETY-LIKE BEHAVIOR; FACTOR MESSENGER-RNA; CENTRAL NUCLEUS; PERIAQUEDUCTAL GRAY; NEUROPEPTIDE-Y; STRIA TERMINALIS; DELIVERY-SYSTEMS; DRUG-DEPENDENCE; BED NUCLEUS; PAIN;
D O I
10.1016/j.neuropharm.2013.09.025
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Because tobacco use has a large negative health and financial impact on society, it is critical to identify the factors that drive excessive use. These factors include the aversive withdrawal symptoms that manifest upon cessation of tobacco use, and may include increases in nociceptive processing. Corticotropin-releasing factor (CRF) signalling in the central amygdala (CeA) has been attributed an important role in: (1) central processing of pain, (2) excessive nicotine use that results in nicotine dependence, and (3) in mediating the aversive symptoms that manifest following cessation of tobacco exposure. Here, we describe three experiments in which the main hypothesis was that CRF/CRF1 receptor (CRF1R) signalling in the CeA mediates nicotine withdrawal-induced increases in nociceptive sensitivity in rats that are dependent on nicotine. In Experiment 1, nicotine-dependent rats withdrawn from chronic intermittent (14-h/day) nicotine vapor exhibited decreased hind paw withdrawal latencies in response to a painful thermal stimulus in the Hargreaves test, and this effect was attenuated by systemic administration of the CRF1R antagonist, R121919. In Experiment 2, nicotine-dependent rats withdrawn from nicotine vapor exhibited robust increases in mRNA for CRF and CRF1Rs in CeA. In Experiment 3, intra-CeA administration of R121919 reduced thermal nociception only in nicotine-dependent rats. Collectively, these results suggest that nicotine dependence increases CRF/CRF1R signalling in the CeA that mediates withdrawal-induced increases in sensitivity to a painful stimulus. Future studies will build on these findings by exploring the hypothesis that nicotine withdrawal-induced reduction in pain thresholds drive excessive nicotine use via CRF/CRF1R signalling pathways. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码:217 / 223
页数:7
相关论文
共 62 条
  • [1] Antinociception induced by chronic exposure of rats to cigarette smoke
    Anderson, KL
    Pinkerton, KE
    Uyeminami, D
    Simons, CT
    Carstens, ML
    Carstens, E
    [J]. NEUROSCIENCE LETTERS, 2004, 366 (01) : 86 - 91
  • [2] The role of corticotropin-releasing factor in depression and anxiety disorders
    Arborelius, L
    Owens, MJ
    Plotsky, PM
    Nemeroff, CB
    [J]. JOURNAL OF ENDOCRINOLOGY, 1999, 160 (01) : 1 - 12
  • [3] Effects of a selective Y2R antagonist, JNJ-31020028, on nicotine abstinence-related social anxiety-like behavior, neuropeptide Y and corticotropin releasing factor mRNA levels in the novelty-seeking phenotype
    Aydin, Cigdem
    Oztan, Ozge
    Isgor, Ceylan
    [J]. BEHAVIOURAL BRAIN RESEARCH, 2011, 222 (02) : 332 - 341
  • [4] CRF and CRF receptors: Role in stress responsivity and other behaviors
    Bale, TL
    Vale, WW
    [J]. ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 2004, 44 : 525 - 557
  • [5] Pain and use of alcohol to manage pain: prevalence and 3-year outcomes among older problem and non-problem drinkers
    Brennan, PL
    Schutte, KK
    Moos, RH
    [J]. ADDICTION, 2005, 100 (06) : 777 - 786
  • [6] Tobacco addiction and the dysregulation of brain stress systems
    Bruijnzeel, Adrie W.
    [J]. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2012, 36 (05) : 1418 - 1441
  • [7] Blockade of CRF1 receptors in the central nucleus of the amygdala attenuates the dysphoria associated with nicotine withdrawal in rats
    Bruijnzeel, Adrie W.
    Ford, Jenna
    Rogers, Jessica A.
    Scheick, Stacey
    Ji, Yue
    Bishnoi, Mahendra
    Alexander, Jon C.
    [J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2012, 101 (01) : 62 - 68
  • [8] Corticotropin-Releasing Factor-1 Receptor Activation Mediates Nicotine Withdrawal-Induced Deficit in Brain Reward Function and Stress-Induced Relapse
    Bruijnzeel, Adrie W.
    Prado, Melissa
    Isaac, Shani
    [J]. BIOLOGICAL PSYCHIATRY, 2009, 66 (02) : 110 - 117
  • [9] In vivo nicotine treatment regulates mesocorticolimbic CREB and ERK signaling in C57Bl/6J mice
    Brunzell, DH
    Russell, DS
    Picciotto, MR
    [J]. JOURNAL OF NEUROCHEMISTRY, 2003, 84 (06) : 1431 - 1441
  • [10] Cohen A, 2013, DOWN BEAT, V80, P22