Thromboembolic complications in adult congenital heart disease: the knowns and the unknowns

被引：9
作者：
Karsenty, Clement [1 ,2 ]
Waldmann, Victor [3 ,4 ,5 ]
Mulder, Barbara [6 ]
Hascoet, Sebastien [7 ]
Ladouceur, Magalie [5 ,8 ]
机构：
[1] Univ Toulouse, CHU Toulouse, Pediat & Congenital Cardiol, 330 Ave Grande Bretagne, F-31300 Toulouse, France
[2] Univ Toulouse, Inst Malad Metab & Cardiovasc, I2MC, INSERM U1048, 1 Ave Jean Poulhes BP84225, Toulouse, France
[3] Paris Descartes Univ, European Georges Pompidou Hosp, AP HP, Electrophysiol Unit,Dept Cardiol, Paris, France
[4] Paris Descartes Univ, European Georges Pompidou Hosp, AP HP, Adult Congenital Heart Dis Unit,Dept Cardiol, Paris, France
[5] Ctr Rech Cardiovasc Paris, INSERM U970, Paris, France
[6] Univ Amsterdam, Dept Cardiol, Locat AMC, Med Ctr, NL-1105 AZ Amsterdam, Netherlands
[7] Paris Sud Univ, Marie Lannelongue Hosp,Inserm U999, Ctr Reference Malformat Cardiaques Congenitales C, Dept Congenital Heart Dis,Grp Hosp Paris St Josep, Orsay, France
[8] Paris Descartes Univ, Hop Europeen Georges Pompidou, AP HP,M3C,Adult Congenital Heart Dis Unit, Ctr Reference Malformat Cardiaques Congenitales C, Paris, France
来源：
CLINICAL RESEARCH IN CARDIOLOGY | 2021年 / 110卷 / 09期
关键词：
Congenital heart disease; Thromboembolic events; Stroke; Management; PEDIATRIC CARDIAC-SURGERY; ATRIAL SEPTAL-DEFECT; INFECTIVE ENDOCARDITIS; FONTAN PROCEDURES; FOLLOW-UP; VENOUS THROMBOEMBOLISM; EMBOLIC COMPLICATIONS; PULMONARY THROMBOSIS; EISENMENGER SYNDROME; FACTOR ABNORMALITIES;
D O I：
10.1007/s00392-020-01746-2
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Despite impressive improvement in long-term survival, adults with congenital heart disease (CHD) remain exposed to a significant cardiovascular morbidity over lifetime. Thromboembolic events (TE) are a major issue. Specific anatomic groups have been shown a particular high risk of TE, including cyanotic heart disease and Fontan circulation. Many intercurrent clinical factors add a substantial risk such as intracardiac medical devices, atrial arrhythmia, endocarditis, or pregnancy. Nevertheless, what is unknown exceeds what is known, especially regarding the management of this heterogenous patient population. Anticoagulation decision should always be individualized weighing balanced with the alternative risk of hemorrhagic complications. In this review, we aim to synthetize existing literature on TE in adults with CHD, discuss management issues, highlight gaps in knowledge, and intend to suggest high priority research.
引用
收藏
页码：1380 / 1391
页数：12
相关论文
共 100 条
  • [1] Short and Long Term Complications of Device Closure of Atrial Septal Defect and Patent Foramen Ovale: Meta-Analysis of 28,142 Patients From 203 Studies
    Abaci, Adnan
    Unlu, Serkan
    Alsancak, Yakup
    Kaya, Ulker
    Sezenoz, Burak
    [J]. CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, 2013, 82 (07) : 1123 - 1138
  • [2] Factors associated with long-term mortality after Fontan procedures: a systematic review
    Alsaied, Tarek
    Bokma, Jouke P.
    Engel, Mark E.
    Kuijpers, Joey M.
    Hanke, Samuel P.
    Zuhlke, Liesl
    Zhang, Bin
    Veldtman, Gruschen R.
    [J]. HEART, 2017, 103 (02) : 104 - 110
  • [3] Strategies for thromboprophylaxis in Fontan circulation: a meta-analysis
    Alsaied, Tarek
    Alsidawi, Said
    Allen, Catherine C.
    Faircloth, Jenna
    Palumbo, Joseph S.
    Veldtman, Gruschen R.
    [J]. HEART, 2015, 101 (21) : 1731 - 1737
  • [4] Cerebrovascular events in adult patients with cyanotic congenital heart disease
    Ammash, N
    Warnes, CA
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1996, 28 (03) : 768 - 772
  • [5] Arnett DK, 2019, CIRCULATION, V140, pE563, DOI [10.1016/j.jacc.2019.03.010, 10.1161/CIR.0000000000000677, 10.1161/CIR.0000000000000678, 10.1016/j.jacc.2019.03.009]
  • [6] Longitudinal Outcomes of Patients With Single Ventricle After the Fontan Procedure
    Atz, Andrew M.
    Zak, Victor
    Mahony, Lynn
    Uzark, Karen
    D'agincourt, Nicholas
    Goldberg, David J.
    Williams, Richard V.
    Breitbart, Roger E.
    Colan, Steven D.
    Burns, Kristin M.
    Margossian, Renee
    Henderson, Heather T.
    Korsin, Rosalind
    Marino, Bradley S.
    Daniels, Kaitlyn
    McCrindle, Brian W.
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2017, 69 (22) : 2735 - 2744
  • [7] Baumgartner H, 2018, EUR HEART J, V39, P1980, DOI [10.1093/eurheartj/ehx636, 10.1093/eurheartj/ehx391]
  • [8] ESC Guidelines for the management of grown-up congenital heart disease (new version 2010)
    Baumgartner, Helmut
    Bonhoeffer, Philipp
    De Groot, Natasja M. S.
    de Haan, Fokko
    Deanfield, John Erik
    Galie, Nazzareno
    Gatzoulis, Michael A.
    Gohlke-Baerwolf, Christa
    Kaemmerer, Harald
    Kilner, Philip
    Meijboom, Folkert
    Mulder, Barbara J. M.
    Oechslin, Erwin
    Oliver, Jose M.
    Serraf, Alain
    Szatmari, Andras
    Thaulow, Erik
    Vouhe, Pascal R.
    Walma, Edmond
    [J]. EUROPEAN HEART JOURNAL, 2010, 31 (23) : 2915 - 2957
  • [9] Geriatric congenital heart disease: a new challenge in the care of adults with congenital heart disease?
    Baumgartner, Helmut
    [J]. EUROPEAN HEART JOURNAL, 2014, 35 (11) : 683 - +
  • [10] Has there been any progress made on pregnancy outcomes among women with pulmonary arterial hypertension?
    Bedard, Elisabeth
    Dimopoulos, Konstantinos
    Gatzoulis, Michael A.
    [J]. EUROPEAN HEART JOURNAL, 2009, 30 (03) : 256 - 265
12345678910