Oncogenic Ras and its role in tumor cell invasion and metastasis

被引：212

作者：

Campbell, PM ^{[1
]}

Der, CJ ^{[1
]}

机构：

[1] Univ N Carolina, Dept Pharmacol, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

来源：

SEMINARS IN CANCER BIOLOGY | 2004年 / 14卷 / 02期

关键词：

Ras; oncogene; signaling; invasion; metastasis;

D O I：

10.1016/j.semcancer.2003.09.015

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The processes by which cancer cells leave the tumor and enter adjacent tissue is known as invasion, whereas metastasis refers to secondary tumor colonization of tissue at a distance from the primary lesion. These two events are the most lethal of cancer phenomena and the signaling mechanisms that govern them are complex. The Ras signaling pathways are well represented in their involvement in tumor initiation, but considerably less is known about their contribution to invasion and metastasis. In this review, we discuss the current evidence for mutant Ras proteins as significant players in these aspects of cancer progression. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：105 / 114

页数：10

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