sox4 And sox11 Function during Xenopus laevis Eye Development

被引：34

作者：

Cizelsky, Wiebke ^{[1
,2
]}

Hempel, Annemarie ^{[1
,2
]}

Metzig, Marlen ^{[3
]}

Tao, Si ^{[1
,2
]}

Hollemann, Thomas ^{[3
]}

Kuehl, Michael ^{[1
]}

Kuehl, Susanne J. ^{[1
]}

机构：

[1] Univ Ulm, Inst Biochem & Mol Biol, D-89069 Ulm, Germany

[2] Univ Ulm, Int Grad Sch Mol Med Ulm, D-89069 Ulm, Germany

[3] Univ Halle Wittenberg, Inst Physiol Chem, D-06108 Halle, Germany

来源：

PLOS ONE | 2013年 / 8卷 / 07期

关键词：

TRANSCRIPTION FACTOR SOX11; SRY-RELATED GENES; CELL-DIFFERENTIATION; EXPRESSION PATTERNS; ZEBRAFISH; INDUCTION; SPECIFICATION; PROGENITORS; SURVIVAL; REVEALS;

D O I：

10.1371/journal.pone.0069372

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

SoxC genes are involved in many developmental processes such as cardiac, lymphoid, and bone development. The SoxC gene family is represented by Sox4, Sox11, and Sox12. Loss of either Sox4 or Sox11 function is lethal during mouse embryogenesis. Here, we demonstrate that sox4 and sox11 are strongly expressed in the developing eye, heart as well as brain in Xenopus laevis. Morpholino oligonucleotide mediated knock-down approaches in anterior neural tissue revealed that interference with either Sox4 or Sox11 function affects eye development. A detailed analysis demonstrated strong effects on eye size and retinal lamination. Neural induction was unaffected upon Sox4 or Sox11 MO injection and early eye field differentiation and cell proliferation were only mildly affected. Depletion of both genes, however, led independently to a significant increase in cell apoptosis in the eye. In summary, Sox4 and Sox11 are required for Xenopus visual system development.

引用

页数：12

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