Subarachnoid Hemorrhage Is It Time for a New Direction?

被引：205
作者：
Cahill, Julian
Zhang, John H. [1 ]
机构：
[1] Loma Linda Univ, Med Ctr, Div Neurosurg, Dept Physiol, Loma Linda, CA 92354 USA
来源：
STROKE | 2009年 / 40卷 / 03期
基金：
美国国家卫生研究院;
关键词：
apoptosis; subarachnoid hemorrhage; vasospasm; early brain injury; CEREBRAL VASOSPASM; MODEL;
D O I：
10.1161/STROKEAHA.108.533315
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Background and Purpose-Despite recent advances in the treatment of patients after subarachnoid hemorrhage, morbidity and mortality rates have failed to improve significantly. Although this was often blamed on vasospasm, is it time to consider alternative etiologies? Summary of Review-Early brain injury (EBI) is a recently described term that describes the immediate injury to the brain after subarachnoid hemorrhage. A number of pathways have been recognized as having a role in the etiology of EBI. This review provides a brief synopsis of EBI and its implications for the future. Conclusions-EBI may be responsible for the detrimental effects seen in patients after subarachnoid hemorrhage. Additional studies are needed to determine the pathophysiology of EBI and to explore potential therapeutic options. (Stroke. 2009; 40[suppl 1]: S86-S87.)
引用
收藏
页码：S86 / S87
页数：2
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