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- [21] Structure-based design of a novel class of herbicidal HPPD inhibitorsABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2016, 252Viner, Russell论文数: 0 引用数: 0 h-index: 0机构: Syngenta, Computat Chem, Bracknell, Berks, England Syngenta, Computat Chem, Bracknell, Berks, EnglandBhonoah, Yunas论文数: 0 引用数: 0 h-index: 0机构: Syngenta, Herbicide Chem, Bracknell, Berks, England Syngenta, Computat Chem, Bracknell, Berks, EnglandLangford, Mike论文数: 0 引用数: 0 h-index: 0机构: Syngenta, Biochem, Bracknell, Berks, England Syngenta, Computat Chem, Bracknell, Berks, EnglandKloer, Daniel论文数: 0 引用数: 0 h-index: 0机构: Syngenta, Struct Biol, Bracknell, Berks, England Syngenta, Computat Chem, Bracknell, Berks, England
- [22] STRUCTURE-BASED DESIGN OF NOVEL NONPEPTIDIC HIV PROTEASE INHIBITORSABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1995, 210 : 25 - MEDILOVASZ, KD论文数: 0 引用数: 0 h-index: 0机构: UPJOHN CO,UPJOHN LABS,KALAMAZOO,MI 49001 UPJOHN CO,UPJOHN LABS,KALAMAZOO,MI 49001MORRIS, JK论文数: 0 引用数: 0 h-index: 0机构: UPJOHN CO,UPJOHN LABS,KALAMAZOO,MI 49001 UPJOHN CO,UPJOHN LABS,KALAMAZOO,MI 49001TOMICH, PK论文数: 0 引用数: 0 h-index: 0机构: UPJOHN CO,UPJOHN LABS,KALAMAZOO,MI 49001 UPJOHN CO,UPJOHN LABS,KALAMAZOO,MI 49001WATENPAUGH, KD论文数: 0 引用数: 0 h-index: 0机构: UPJOHN CO,UPJOHN LABS,KALAMAZOO,MI 49001 UPJOHN CO,UPJOHN LABS,KALAMAZOO,MI 49001HOWE, WJ论文数: 0 引用数: 0 h-index: 0机构: UPJOHN CO,UPJOHN LABS,KALAMAZOO,MI 49001 UPJOHN CO,UPJOHN LABS,KALAMAZOO,MI 49001DOLAK, LA论文数: 0 引用数: 0 h-index: 0机构: UPJOHN CO,UPJOHN LABS,KALAMAZOO,MI 49001 UPJOHN CO,UPJOHN LABS,KALAMAZOO,MI 49001ROMINES, KR论文数: 0 引用数: 0 h-index: 0机构: UPJOHN CO,UPJOHN LABS,KALAMAZOO,MI 49001 UPJOHN CO,UPJOHN LABS,KALAMAZOO,MI 49001
- [23] Identification of novel tyrosinase inhibitors by structure-based computational approachFEBS JOURNAL, 2008, 275 : 177 - 177Takahashi, S.论文数: 0 引用数: 0 h-index: 0机构: Inst Theoret Med Inc, Yokohama, Kanagawa, Japan Inst Theoret Med Inc, Yokohama, Kanagawa, JapanKamiya, T.论文数: 0 引用数: 0 h-index: 0机构: Hinaki Shinayaku Co Ltd, Tokyo, Japan Inst Theoret Med Inc, Yokohama, Kanagawa, JapanTakeuchi, Shin-Ichiro论文数: 0 引用数: 0 h-index: 0机构: Hinaki Shinayaku Co Ltd, Tokyo, Japan Inst Theoret Med Inc, Yokohama, Kanagawa, JapanNezu, T.论文数: 0 引用数: 0 h-index: 0机构: Inst Theoret Med Inc, Yokohama, Kanagawa, JapanSaeki, K.论文数: 0 引用数: 0 h-index: 0机构: Tokyo Univ Sci, Fac Pharmaceut Sci, Dept Biochem, Chiba, Japan Inst Theoret Med Inc, Yokohama, Kanagawa, JapanTakasawa, R.论文数: 0 引用数: 0 h-index: 0机构: Tokyo Univ Sci, Fac Pharmaceut Sci, Dept Biochem, Chiba, Japan Inst Theoret Med Inc, Yokohama, Kanagawa, JapanYoshimori, A.论文数: 0 引用数: 0 h-index: 0机构: Inst Theoret Med Inc, Yokohama, Kanagawa, Japan Inst Theoret Med Inc, Yokohama, Kanagawa, JapanEbizuka, S.论文数: 0 引用数: 0 h-index: 0机构: Hinaki Shinayaku Co Ltd, Tokyo, Japan Inst Theoret Med Inc, Yokohama, Kanagawa, JapanAbe, T.论文数: 0 引用数: 0 h-index: 0机构: Hinaki Shinayaku Co Ltd, Tokyo, Japan Inst Theoret Med Inc, Yokohama, Kanagawa, JapanTanuma, Sei-Ichi论文数: 0 引用数: 0 h-index: 0机构: Tokyo Univ Sci, Fac Pharmaceut Sci, Dept Biochem, Chiba, Japan Tokyo Univ Sci, Genome & Drug Res Ctr, Chiba, Japan Inst Theoret Med Inc, Yokohama, Kanagawa, Japan
- [24] SIRT6 inhibition as a novel approach for treating Acute Myeloid LeukemiaEUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2017, 47 : 156 - 156Cagnetta, A.论文数: 0 引用数: 0 h-index: 0机构: Univ Genoa, Genoa, Italy Univ Genoa, Genoa, ItalySoncini, D.论文数: 0 引用数: 0 h-index: 0机构: Univ Genoa, Genoa, Italy Univ Genoa, Genoa, ItalyMinetto, P.论文数: 0 引用数: 0 h-index: 0机构: Univ Genoa, Genoa, Italy Univ Genoa, Genoa, ItalyMiglino, M.论文数: 0 引用数: 0 h-index: 0机构: Univ Genoa, Genoa, Italy Univ Genoa, Genoa, ItalyColombo, N.论文数: 0 引用数: 0 h-index: 0机构: Univ Genoa, Genoa, Italy Univ Genoa, Genoa, ItalyCarminati, E.论文数: 0 引用数: 0 h-index: 0机构: Univ Genoa, Genoa, Italy Univ Genoa, Genoa, ItalyBruzzone, S.论文数: 0 引用数: 0 h-index: 0机构: Univ Genoa, Genoa, Italy Univ Genoa, Genoa, ItalyAlessio, N.论文数: 0 引用数: 0 h-index: 0机构: Univ Genoa, Genoa, Italy Univ Genoa, Genoa, ItalyMarco, G.论文数: 0 引用数: 0 h-index: 0机构: Univ Genoa, Genoa, Italy Univ Genoa, Genoa, ItalyRoberto, L.论文数: 0 引用数: 0 h-index: 0机构: Univ Genoa, Genoa, Italy Univ Genoa, Genoa, ItalyCea, M.论文数: 0 引用数: 0 h-index: 0机构: Univ Genoa, Genoa, Italy Univ Genoa, Genoa, Italy
- [25] Structure-based design of LpxC inhibitors selective against histone deacetylaseABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2013, 246Miller, Matthew D.论文数: 0 引用数: 0 h-index: 0机构: AstraZeneca, Dept Computat Sci, Waltham, MA 02451 USA AstraZeneca, Dept Computat Sci, Waltham, MA 02451 USAHill, Pamela论文数: 0 引用数: 0 h-index: 0机构: AstraZeneca, Dept Chem, Waltham, MA 02451 USA AstraZeneca, Dept Computat Sci, Waltham, MA 02451 USAGagnon, Moriah论文数: 0 引用数: 0 h-index: 0机构: AstraZeneca, Dept Chem, Waltham, MA 02451 USA AstraZeneca, Dept Computat Sci, Waltham, MA 02451 USAGrebe, Tyler论文数: 0 引用数: 0 h-index: 0机构: AstraZeneca, Dept Chem, Waltham, MA 02451 USA AstraZeneca, Dept Computat Sci, Waltham, MA 02451 USAChoy, Allison论文数: 0 引用数: 0 h-index: 0机构: AstraZeneca, Dept Chem, Waltham, MA 02451 USA AstraZeneca, Dept Computat Sci, Waltham, MA 02451 USABenenato, Kerry论文数: 0 引用数: 0 h-index: 0机构: AstraZeneca, Dept Chem, Waltham, MA 02451 USA AstraZeneca, Dept Computat Sci, Waltham, MA 02451 USAMarone, Valerie论文数: 0 引用数: 0 h-index: 0机构: AstraZeneca, Dept Chem, Waltham, MA 02451 USA AstraZeneca, Dept Computat Sci, Waltham, MA 02451 USARoss, Philip论文数: 0 引用数: 0 h-index: 0机构: AstraZeneca, Dept Biosci, Waltham, MA 02451 USA AstraZeneca, Dept Computat Sci, Waltham, MA 02451 USAHale, Michael论文数: 0 引用数: 0 h-index: 0机构: AstraZeneca, Dept Chem, Waltham, MA 02451 USA AstraZeneca, Dept Computat Sci, Waltham, MA 02451 USA
- [26] Structure-based approaches in the design of GSK-3 selective inhibitorsCURRENT PROTEIN & PEPTIDE SCIENCE, 2007, 8 (04) : 352 - 364Patel, Dhilon S.论文数: 0 引用数: 0 h-index: 0机构: Natl Inst Pharmaceut Educ & Res, Dept Med Chem, Punjab 160062, India Natl Inst Pharmaceut Educ & Res, Dept Med Chem, Punjab 160062, IndiaDessalew, Nigus论文数: 0 引用数: 0 h-index: 0机构: Natl Inst Pharmaceut Educ & Res, Dept Med Chem, Punjab 160062, India Natl Inst Pharmaceut Educ & Res, Dept Med Chem, Punjab 160062, IndiaLqbal, Pansy论文数: 0 引用数: 0 h-index: 0机构: Natl Inst Pharmaceut Educ & Res, Dept Med Chem, Punjab 160062, India Natl Inst Pharmaceut Educ & Res, Dept Med Chem, Punjab 160062, IndiaBharatam, Prasad V.论文数: 0 引用数: 0 h-index: 0机构: Natl Inst Pharmaceut Educ & Res, Dept Med Chem, Punjab 160062, India Natl Inst Pharmaceut Educ & Res, Dept Med Chem, Punjab 160062, India
- [27] Identification of immunoproteasome selective inhibitors with structure-based molecular design approachesABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2014, 247论文数: 引用数: h-index:机构:Bellavista, Elena论文数: 0 引用数: 0 h-index: 0机构: Univ Bologna, Alma Mater Studiorum, Dept Expt Diagnost & Specialty Med DIMES, Bologna, Italy Univ Bologna, Alma Mater Studiorum, Interdept Ctr Studies Biophys Bioinformat & Bioco, Bologna, Italy Univ Bologna, Alma Mater Studiorum, Dept Expt Diagnost & Specialty Med DIMES, Bologna, ItalyAndreoli, Federico论文数: 0 引用数: 0 h-index: 0机构: Univ Bologna, Alma Mater Studiorum, Dept Expt Diagnost & Specialty Med DIMES, Bologna, Italy Univ Bologna, Alma Mater Studiorum, Dept Expt Diagnost & Specialty Med DIMES, Bologna, ItalyBortolotti, Massimo论文数: 0 引用数: 0 h-index: 0机构: Univ Bologna, Alma Mater Studiorum, Dept Expt Diagnost & Specialty Med DIMES, Bologna, Italy Univ Bologna, Alma Mater Studiorum, Dept Expt Diagnost & Specialty Med DIMES, Bologna, ItalyMishto, Michele论文数: 0 引用数: 0 h-index: 0机构: Charite, Inst Biochem, D-13353 Berlin, Germany Univ Bologna, Alma Mater Studiorum, Ctr Interdipartimentale Ric Cancro Giorgio Prodi, Bologna, Italy Univ Bologna, Alma Mater Studiorum, Dept Expt Diagnost & Specialty Med DIMES, Bologna, ItalyMartucci, Morena论文数: 0 引用数: 0 h-index: 0机构: Univ Bologna, Alma Mater Studiorum, Dept Expt Diagnost & Specialty Med DIMES, Bologna, Italy Univ Bologna, Alma Mater Studiorum, Dept Expt Diagnost & Specialty Med DIMES, Bologna, ItalyBolognesi, Andrea论文数: 0 引用数: 0 h-index: 0机构: Univ Bologna, Alma Mater Studiorum, Dept Expt Diagnost & Specialty Med DIMES, Bologna, Italy Univ Bologna, Alma Mater Studiorum, Dept Expt Diagnost & Specialty Med DIMES, Bologna, ItalyFranceschi, Claudio论文数: 0 引用数: 0 h-index: 0机构: Univ Bologna, Alma Mater Studiorum, Dept Expt Diagnost & Specialty Med DIMES, Bologna, Italy Univ Bologna, Alma Mater Studiorum, Interdept Ctr Studies Biophys Bioinformat & Bioco, Bologna, Italy Univ Bologna, Alma Mater Studiorum, Dept Expt Diagnost & Specialty Med DIMES, Bologna, Italy论文数: 引用数: h-index:机构:
- [28] Structure-Based Drug Design of Bcl-XL Selective InhibitorsACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 2021, 77 : A17 - A17Judge, R.论文数: 0 引用数: 0 h-index: 0机构: AbbVie, Struct Biol GPRD R467, Lake Bluff, IL USA AbbVie, Struct Biol GPRD R467, Lake Bluff, IL USA
- [29] Structure-Based Design of Potent and Selective CK1γ InhibitorsACS MEDICINAL CHEMISTRY LETTERS, 2012, 3 (12): : 1059 - 1064Huang, Hongbing论文数: 0 引用数: 0 h-index: 0机构: Amgen Inc, Dept Med Chem, Cambridge, MA 02142 USA Amgen Inc, Dept Med Chem, Cambridge, MA 02142 USAAcquaviva, Lisa论文数: 0 引用数: 0 h-index: 0机构: Amgen Inc, Dept Oncol Res, Cambridge, MA 02142 USA Amgen Inc, Dept Med Chem, Cambridge, MA 02142 USABerry, Virginia论文数: 0 引用数: 0 h-index: 0机构: Amgen Inc, Dept Pharmacokinet & Drug Metab, Cambridge, MA 02142 USA Amgen Inc, Dept Med Chem, Cambridge, MA 02142 USABregman, Howard论文数: 0 引用数: 0 h-index: 0机构: Amgen Inc, Dept Med Chem, Cambridge, MA 02142 USA Amgen Inc, Dept Med Chem, Cambridge, MA 02142 USAChakka, Nagasree论文数: 0 引用数: 0 h-index: 0机构: Amgen Inc, Dept Med Chem, Cambridge, MA 02142 USA Amgen Inc, Dept Med Chem, Cambridge, MA 02142 USAO'Connor, Anne论文数: 0 引用数: 0 h-index: 0机构: Amgen Inc, Dept Mol Struct, Cambridge, MA 02142 USA Amgen Inc, Dept Med Chem, Cambridge, MA 02142 USADiMauro, Erin F.论文数: 0 引用数: 0 h-index: 0机构: Amgen Inc, Dept Med Chem, Cambridge, MA 02142 USA Amgen Inc, Dept Med Chem, Cambridge, MA 02142 USADovey, Jennifer论文数: 0 引用数: 0 h-index: 0机构: Amgen Inc, Dept Oncol Res, Cambridge, MA 02142 USA Amgen Inc, Dept Med Chem, Cambridge, MA 02142 USAEpstein, Oleg论文数: 0 引用数: 0 h-index: 0机构: Amgen Inc, Dept Med Chem, Cambridge, MA 02142 USA Amgen Inc, Dept Med Chem, Cambridge, MA 02142 USAGrubinska, Barbara论文数: 0 引用数: 0 h-index: 0机构: Amgen Inc, Dept Oncol Res, Cambridge, MA 02142 USA Amgen Inc, Dept Med Chem, Cambridge, MA 02142 USAGoldstein, Jon论文数: 0 引用数: 0 h-index: 0机构: Amgen Inc, Dept Oncol Res, Cambridge, MA 02142 USA Amgen Inc, Dept Med Chem, Cambridge, MA 02142 USAGunaydin, Hakan论文数: 0 引用数: 0 h-index: 0机构: Amgen Inc, Dept Mol Struct, Cambridge, MA 02142 USA Amgen Inc, Dept Med Chem, Cambridge, MA 02142 USAHua, Zihao论文数: 0 引用数: 0 h-index: 0机构: Amgen Inc, Dept Med Chem, Cambridge, MA 02142 USA Amgen Inc, Dept Med Chem, Cambridge, MA 02142 USAHuang, Xin论文数: 0 引用数: 0 h-index: 0机构: Amgen Inc, Dept Mol Struct, Cambridge, MA 02142 USA Amgen Inc, Dept Med Chem, Cambridge, MA 02142 USAHuang, Liyue论文数: 0 引用数: 0 h-index: 0机构: Amgen Inc, Dept Pharmacokinet & Drug Metab, Cambridge, MA 02142 USA Amgen Inc, Dept Med Chem, Cambridge, MA 02142 USAHuman, Jason论文数: 0 引用数: 0 h-index: 0机构: Amgen Inc, Dept Med Chem, Cambridge, MA 02142 USA Amgen Inc, Dept Med Chem, Cambridge, MA 02142 USALong, Alex论文数: 0 引用数: 0 h-index: 0机构: Amgen Inc, Dept Mol Struct, Cambridge, MA 02142 USA Amgen Inc, Dept Med Chem, Cambridge, MA 02142 USANewcomb, John论文数: 0 引用数: 0 h-index: 0机构: Amgen Inc, Dept Oncol Res, Cambridge, MA 02142 USA Amgen Inc, Dept Med Chem, Cambridge, MA 02142 USAPatel, Vinod F.论文数: 0 引用数: 0 h-index: 0机构: Amgen Inc, Dept Med Chem, Cambridge, MA 02142 USA Amgen Inc, Dept Med Chem, Cambridge, MA 02142 USASaffran, Doug论文数: 0 引用数: 0 h-index: 0机构: Amgen Inc, Dept Oncol Res, Cambridge, MA 02142 USA Amgen Inc, Dept Med Chem, Cambridge, MA 02142 USASerafino, Randy论文数: 0 引用数: 0 h-index: 0机构: Amgen Inc, Dept Oncol Res, Cambridge, MA 02142 USA Amgen Inc, Dept Med Chem, Cambridge, MA 02142 USASchneider, Steve论文数: 0 引用数: 0 h-index: 0机构: Amgen Inc, Dept Mol Struct, Cambridge, MA 02142 USA Amgen Inc, Dept Med Chem, Cambridge, MA 02142 USAStrathdee, Craig论文数: 0 引用数: 0 h-index: 0机构: Amgen Inc, Dept Oncol Res, Cambridge, MA 02142 USA Amgen Inc, Dept Med Chem, Cambridge, MA 02142 USATang, Jin论文数: 0 引用数: 0 h-index: 0机构: Amgen Inc, Dept Mol Struct, Cambridge, MA 02142 USA Amgen Inc, Dept Med Chem, Cambridge, MA 02142 USATurci, Susan论文数: 0 引用数: 0 h-index: 0机构: Amgen Inc, Dept Oncol Res, Cambridge, MA 02142 USA Amgen Inc, Dept Med Chem, Cambridge, MA 02142 USAWhite, Ryan论文数: 0 引用数: 0 h-index: 0机构: Amgen Inc, Dept Med Chem, Cambridge, MA 02142 USA Amgen Inc, Dept Med Chem, Cambridge, MA 02142 USAYu, Violeta论文数: 0 引用数: 0 h-index: 0机构: Amgen Inc, Dept Mol Struct, Cambridge, MA 02142 USA Amgen Inc, Dept Med Chem, Cambridge, MA 02142 USAZhao, Huilin论文数: 0 引用数: 0 h-index: 0机构: Amgen Inc, Dept Mol Struct, Cambridge, MA 02142 USA Amgen Inc, Dept Med Chem, Cambridge, MA 02142 USAWilson, Cindy论文数: 0 引用数: 0 h-index: 0机构: Amgen Inc, Dept Oncol Res, Cambridge, MA 02142 USA Amgen Inc, Dept Med Chem, Cambridge, MA 02142 USAMartin, Matthew W.论文数: 0 引用数: 0 h-index: 0机构: Amgen Inc, Dept Med Chem, Cambridge, MA 02142 USA Amgen Inc, Dept Med Chem, Cambridge, MA 02142 USA
- [30] Structure-Based Design of Selective Salt-Inducible Kinase InhibitorsJOURNAL OF MEDICINAL CHEMISTRY, 2021, 64 (12) : 8142 - 8160论文数: 引用数: h-index:机构:Rak, Marcel论文数: 0 引用数: 0 h-index: 0机构: Goethe Univ Frankfurt, Inst Pharmaceut Chem, D-60438 Frankfurt, Germany Goethe Univ Frankfurt, Buchmann Inst Life Sci, Struct Genom Consortium SGC, D-60438 Frankfurt, Germany Goethe Univ Frankfurt, Inst Pharmaceut Chem, D-60438 Frankfurt, GermanyRaab, Monika论文数: 0 引用数: 0 h-index: 0机构: Goethe Univ Frankfurt, Sch Med, Dept Obstet & Gynaecol, D-60590 Frankfurt, Germany Goethe Univ Frankfurt, Inst Pharmaceut Chem, D-60438 Frankfurt, GermanyBerger, Lena M.论文数: 0 引用数: 0 h-index: 0机构: Goethe Univ Frankfurt, Inst Pharmaceut Chem, D-60438 Frankfurt, Germany Goethe Univ Frankfurt, Buchmann Inst Life Sci, Struct Genom Consortium SGC, D-60438 Frankfurt, Germany Goethe Univ Frankfurt, Inst Pharmaceut Chem, D-60438 Frankfurt, GermanyKronenberger, Thales论文数: 0 引用数: 0 h-index: 0机构: Univ Hosp Tubingen, Dept Internal Med 8, D-72076 Tubingen, Germany Univ Eastern Finland, Sch Pharm, Kuopio 70210, Finland Goethe Univ Frankfurt, Inst Pharmaceut Chem, D-60438 Frankfurt, GermanyJoerger, Andreas C.论文数: 0 引用数: 0 h-index: 0机构: Goethe Univ Frankfurt, Inst Pharmaceut Chem, D-60438 Frankfurt, Germany Goethe Univ Frankfurt, Buchmann Inst Life Sci, Struct Genom Consortium SGC, D-60438 Frankfurt, Germany Goethe Univ Frankfurt, Inst Pharmaceut Chem, D-60438 Frankfurt, GermanyBerger, Benedict-Tilman论文数: 0 引用数: 0 h-index: 0机构: Goethe Univ Frankfurt, Inst Pharmaceut Chem, D-60438 Frankfurt, Germany Goethe Univ Frankfurt, Buchmann Inst Life Sci, Struct Genom Consortium SGC, D-60438 Frankfurt, Germany Goethe Univ Frankfurt, Inst Pharmaceut Chem, D-60438 Frankfurt, GermanyAbdi, Ismahan论文数: 0 引用数: 0 h-index: 0机构: Goethe Univ Frankfurt, Inst Pharmaceut Chem, D-60438 Frankfurt, Germany Goethe Univ Frankfurt, Buchmann Inst Life Sci, Struct Genom Consortium SGC, D-60438 Frankfurt, Germany Goethe Univ Frankfurt, Inst Pharmaceut Chem, D-60438 Frankfurt, Germany论文数: 引用数: h-index:机构:Poso, Antti论文数: 0 引用数: 0 h-index: 0机构: Univ Hosp Tubingen, Dept Internal Med 8, D-72076 Tubingen, Germany Univ Eastern Finland, Sch Pharm, Kuopio 70210, Finland Goethe Univ Frankfurt, Inst Pharmaceut Chem, D-60438 Frankfurt, Germany论文数: 引用数: h-index:机构:Sanhaji, Mourad论文数: 0 引用数: 0 h-index: 0机构: Goethe Univ Frankfurt, Sch Med, Dept Obstet & Gynaecol, D-60590 Frankfurt, Germany Goethe Univ Frankfurt, Inst Pharmaceut Chem, D-60438 Frankfurt, GermanyKnapp, Stefan论文数: 0 引用数: 0 h-index: 0机构: Goethe Univ Frankfurt, Inst Pharmaceut Chem, D-60438 Frankfurt, Germany Goethe Univ Frankfurt, Buchmann Inst Life Sci, Struct Genom Consortium SGC, D-60438 Frankfurt, Germany German Translat Canc Network DKTK, D-60438 Frankfurt, Germany Frankfurt Canc Inst FCI, D-60438 Frankfurt, Germany Goethe Univ Frankfurt, Inst Pharmaceut Chem, D-60438 Frankfurt, Germany