Moving towards disease modification in inflammatory bowel disease therapy
被引:69
作者:
Allen, Patrick B.
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机构:
Ulster Hosp, SE Trust, Dept Gastroenterol, Belfast, Antrim, North IrelandUlster Hosp, SE Trust, Dept Gastroenterol, Belfast, Antrim, North Ireland
Allen, Patrick B.
[1
]
Peyrin-Biroulet, Laurent
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h-index: 0
机构:
INSERM, U954, Vandoeuvre Les Nancy, France
Univ Hosp Nancy, Dept Hepatogastroenterol, Vandoeuvre Les Nancy, FranceUlster Hosp, SE Trust, Dept Gastroenterol, Belfast, Antrim, North Ireland
Peyrin-Biroulet, Laurent
[2
,3
]
机构:
[1] Ulster Hosp, SE Trust, Dept Gastroenterol, Belfast, Antrim, North Ireland
[2] INSERM, U954, Vandoeuvre Les Nancy, France
[3] Univ Hosp Nancy, Dept Hepatogastroenterol, Vandoeuvre Les Nancy, France
Purpose of reviewThe inflammatory bowel diseases (IBDs) are chronic disabling conditions. Despite the benefits of anti-tumor necrosis factor (TNF)- agents in improving quality of life and reducing the need for surgeries, overall only one-third of patients are in clinical remission at 1 year and loss of response is frequent. It seems clear that treatment must go beyond alleviation of symptoms in IBD. It is important that treatment targets in IBD will ensure mucosal healing and deep remission. Recent findingsThe induction of deep remission might be the best way to alter the natural course of these diseases by preventing disability and bowel damage. New disability indices and the new Crohn's disease damage score have recently been developed and they can be used to evaluate the long-term effect on patients and as new endpoints in trials. Early intervention with disease-modifying anti-IBD drugs (DMAIDs) should be considered in patients with poor prognostic factors. SummaryNew therapeutic targets in IBD patients who failed anti-TNF- therapy are urgently required, and tofacitinib, vedolizumab and ustekinumab appear to be the most promising drugs. Herein, we review the new and current trends in IBD therapy, with the final aim of changing disease course and patients' lives by both improving quality of life and avoiding disability.
机构:
St Vincents Hosp, Melbourne, Vic 3065, Australia
No Trust, Causeway Hosp, Belfast, Antrim, North IrelandSt Vincents Hosp, Melbourne, Vic 3065, Australia
Allen, P. B.
;
Kamm, M. A.
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机构:
St Vincents Hosp, Melbourne, Vic 3065, Australia
Univ Melbourne, Melbourne, Vic, Australia
Univ London Imperial Coll Sci Technol & Med, London, EnglandSt Vincents Hosp, Melbourne, Vic 3065, Australia
Kamm, M. A.
;
Peyrin-Biroulet, L.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hosp Nancy, Vandoeuvre Les Nancy, FranceSt Vincents Hosp, Melbourne, Vic 3065, Australia
Peyrin-Biroulet, L.
;
Studd, C.
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机构:
St Vincents Hosp, Melbourne, Vic 3065, AustraliaSt Vincents Hosp, Melbourne, Vic 3065, Australia
Studd, C.
;
Mc Dowell, C.
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机构:
Clin Res Support Council, Belfast, Antrim, North IrelandSt Vincents Hosp, Melbourne, Vic 3065, Australia
Mc Dowell, C.
;
Allen, B. C. M.
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h-index: 0
机构:
No Trust, Causeway Hosp, Belfast, Antrim, North IrelandSt Vincents Hosp, Melbourne, Vic 3065, Australia
Allen, B. C. M.
;
Connell, W. R.
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h-index: 0
机构:
St Vincents Hosp, Melbourne, Vic 3065, AustraliaSt Vincents Hosp, Melbourne, Vic 3065, Australia
Connell, W. R.
;
De Cruz, P. P.
论文数: 0引用数: 0
h-index: 0
机构:
St Vincents Hosp, Melbourne, Vic 3065, Australia
Univ Melbourne, Melbourne, Vic, AustraliaSt Vincents Hosp, Melbourne, Vic 3065, Australia
De Cruz, P. P.
;
Bell, S. J.
论文数: 0引用数: 0
h-index: 0
机构:
St Vincents Hosp, Melbourne, Vic 3065, AustraliaSt Vincents Hosp, Melbourne, Vic 3065, Australia
Bell, S. J.
;
Elliot, R. P.
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h-index: 0
机构:
St Vincents Hosp, Melbourne, Vic 3065, AustraliaSt Vincents Hosp, Melbourne, Vic 3065, Australia
Elliot, R. P.
;
Brown, S.
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St Vincents Hosp, Melbourne, Vic 3065, AustraliaSt Vincents Hosp, Melbourne, Vic 3065, Australia
Brown, S.
;
Desmond, P. V.
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St Vincents Hosp, Melbourne, Vic 3065, AustraliaSt Vincents Hosp, Melbourne, Vic 3065, Australia
Desmond, P. V.
;
Lemann, M.
论文数: 0引用数: 0
h-index: 0
机构:
Hop St Lazare, Serv Gastroenterol, F-75475 Paris, FranceSt Vincents Hosp, Melbourne, Vic 3065, Australia
Lemann, M.
;
Colombel, J-F.
论文数: 0引用数: 0
h-index: 0
机构:
Hop Claude Huriez, Dept Hepatogastroenterol, Lille, FranceSt Vincents Hosp, Melbourne, Vic 3065, Australia
机构:
Univ Edinburgh, Western Gen Hosp, Gastrointestinal Unit, Dept Med Sci,Sch Clin & Mol Med, Edinburgh EH4 2XU, Midlothian, ScotlandUniv Edinburgh, Western Gen Hosp, Gastrointestinal Unit, Dept Med Sci,Sch Clin & Mol Med, Edinburgh EH4 2XU, Midlothian, Scotland
Arnott, IDR
;
Landers, CJ
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机构:Univ Edinburgh, Western Gen Hosp, Gastrointestinal Unit, Dept Med Sci,Sch Clin & Mol Med, Edinburgh EH4 2XU, Midlothian, Scotland
Landers, CJ
;
Nimmo, EJ
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机构:Univ Edinburgh, Western Gen Hosp, Gastrointestinal Unit, Dept Med Sci,Sch Clin & Mol Med, Edinburgh EH4 2XU, Midlothian, Scotland
Nimmo, EJ
;
Drummond, HE
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机构:Univ Edinburgh, Western Gen Hosp, Gastrointestinal Unit, Dept Med Sci,Sch Clin & Mol Med, Edinburgh EH4 2XU, Midlothian, Scotland
Drummond, HE
;
Smith, BKR
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机构:Univ Edinburgh, Western Gen Hosp, Gastrointestinal Unit, Dept Med Sci,Sch Clin & Mol Med, Edinburgh EH4 2XU, Midlothian, Scotland
Smith, BKR
;
Targan, SR
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机构:Univ Edinburgh, Western Gen Hosp, Gastrointestinal Unit, Dept Med Sci,Sch Clin & Mol Med, Edinburgh EH4 2XU, Midlothian, Scotland
Targan, SR
;
Satsangi, J
论文数: 0引用数: 0
h-index: 0
机构:Univ Edinburgh, Western Gen Hosp, Gastrointestinal Unit, Dept Med Sci,Sch Clin & Mol Med, Edinburgh EH4 2XU, Midlothian, Scotland
机构:
Univ Henri Poincare 1, Dept Hepatogastroenterol, Univ Hosp Nancy, Inserm U954, F-54511 Vandoeuvre Les Nancy, FranceUniv Henri Poincare 1, Dept Hepatogastroenterol, Univ Hosp Nancy, Inserm U954, F-54511 Vandoeuvre Les Nancy, France
Billioud, Vincent
;
Sandborn, William J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Div Gastroenterol, La Jolla, CA 92093 USAUniv Henri Poincare 1, Dept Hepatogastroenterol, Univ Hosp Nancy, Inserm U954, F-54511 Vandoeuvre Les Nancy, France
Sandborn, William J.
;
Peyrin-Biroulet, Laurent
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h-index: 0
机构:
Univ Henri Poincare 1, Dept Hepatogastroenterol, Univ Hosp Nancy, Inserm U954, F-54511 Vandoeuvre Les Nancy, FranceUniv Henri Poincare 1, Dept Hepatogastroenterol, Univ Hosp Nancy, Inserm U954, F-54511 Vandoeuvre Les Nancy, France
机构:
St Vincents Hosp, Melbourne, Vic 3065, Australia
No Trust, Causeway Hosp, Belfast, Antrim, North IrelandSt Vincents Hosp, Melbourne, Vic 3065, Australia
Allen, P. B.
;
Kamm, M. A.
论文数: 0引用数: 0
h-index: 0
机构:
St Vincents Hosp, Melbourne, Vic 3065, Australia
Univ Melbourne, Melbourne, Vic, Australia
Univ London Imperial Coll Sci Technol & Med, London, EnglandSt Vincents Hosp, Melbourne, Vic 3065, Australia
Kamm, M. A.
;
Peyrin-Biroulet, L.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hosp Nancy, Vandoeuvre Les Nancy, FranceSt Vincents Hosp, Melbourne, Vic 3065, Australia
Peyrin-Biroulet, L.
;
Studd, C.
论文数: 0引用数: 0
h-index: 0
机构:
St Vincents Hosp, Melbourne, Vic 3065, AustraliaSt Vincents Hosp, Melbourne, Vic 3065, Australia
Studd, C.
;
Mc Dowell, C.
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h-index: 0
机构:
Clin Res Support Council, Belfast, Antrim, North IrelandSt Vincents Hosp, Melbourne, Vic 3065, Australia
Mc Dowell, C.
;
Allen, B. C. M.
论文数: 0引用数: 0
h-index: 0
机构:
No Trust, Causeway Hosp, Belfast, Antrim, North IrelandSt Vincents Hosp, Melbourne, Vic 3065, Australia
Allen, B. C. M.
;
Connell, W. R.
论文数: 0引用数: 0
h-index: 0
机构:
St Vincents Hosp, Melbourne, Vic 3065, AustraliaSt Vincents Hosp, Melbourne, Vic 3065, Australia
Connell, W. R.
;
De Cruz, P. P.
论文数: 0引用数: 0
h-index: 0
机构:
St Vincents Hosp, Melbourne, Vic 3065, Australia
Univ Melbourne, Melbourne, Vic, AustraliaSt Vincents Hosp, Melbourne, Vic 3065, Australia
De Cruz, P. P.
;
Bell, S. J.
论文数: 0引用数: 0
h-index: 0
机构:
St Vincents Hosp, Melbourne, Vic 3065, AustraliaSt Vincents Hosp, Melbourne, Vic 3065, Australia
Bell, S. J.
;
Elliot, R. P.
论文数: 0引用数: 0
h-index: 0
机构:
St Vincents Hosp, Melbourne, Vic 3065, AustraliaSt Vincents Hosp, Melbourne, Vic 3065, Australia
Elliot, R. P.
;
Brown, S.
论文数: 0引用数: 0
h-index: 0
机构:
St Vincents Hosp, Melbourne, Vic 3065, AustraliaSt Vincents Hosp, Melbourne, Vic 3065, Australia
Brown, S.
;
Desmond, P. V.
论文数: 0引用数: 0
h-index: 0
机构:
St Vincents Hosp, Melbourne, Vic 3065, AustraliaSt Vincents Hosp, Melbourne, Vic 3065, Australia
Desmond, P. V.
;
Lemann, M.
论文数: 0引用数: 0
h-index: 0
机构:
Hop St Lazare, Serv Gastroenterol, F-75475 Paris, FranceSt Vincents Hosp, Melbourne, Vic 3065, Australia
Lemann, M.
;
Colombel, J-F.
论文数: 0引用数: 0
h-index: 0
机构:
Hop Claude Huriez, Dept Hepatogastroenterol, Lille, FranceSt Vincents Hosp, Melbourne, Vic 3065, Australia
机构:
Univ Edinburgh, Western Gen Hosp, Gastrointestinal Unit, Dept Med Sci,Sch Clin & Mol Med, Edinburgh EH4 2XU, Midlothian, ScotlandUniv Edinburgh, Western Gen Hosp, Gastrointestinal Unit, Dept Med Sci,Sch Clin & Mol Med, Edinburgh EH4 2XU, Midlothian, Scotland
Arnott, IDR
;
Landers, CJ
论文数: 0引用数: 0
h-index: 0
机构:Univ Edinburgh, Western Gen Hosp, Gastrointestinal Unit, Dept Med Sci,Sch Clin & Mol Med, Edinburgh EH4 2XU, Midlothian, Scotland
Landers, CJ
;
Nimmo, EJ
论文数: 0引用数: 0
h-index: 0
机构:Univ Edinburgh, Western Gen Hosp, Gastrointestinal Unit, Dept Med Sci,Sch Clin & Mol Med, Edinburgh EH4 2XU, Midlothian, Scotland
Nimmo, EJ
;
Drummond, HE
论文数: 0引用数: 0
h-index: 0
机构:Univ Edinburgh, Western Gen Hosp, Gastrointestinal Unit, Dept Med Sci,Sch Clin & Mol Med, Edinburgh EH4 2XU, Midlothian, Scotland
Drummond, HE
;
Smith, BKR
论文数: 0引用数: 0
h-index: 0
机构:Univ Edinburgh, Western Gen Hosp, Gastrointestinal Unit, Dept Med Sci,Sch Clin & Mol Med, Edinburgh EH4 2XU, Midlothian, Scotland
Smith, BKR
;
Targan, SR
论文数: 0引用数: 0
h-index: 0
机构:Univ Edinburgh, Western Gen Hosp, Gastrointestinal Unit, Dept Med Sci,Sch Clin & Mol Med, Edinburgh EH4 2XU, Midlothian, Scotland
Targan, SR
;
Satsangi, J
论文数: 0引用数: 0
h-index: 0
机构:Univ Edinburgh, Western Gen Hosp, Gastrointestinal Unit, Dept Med Sci,Sch Clin & Mol Med, Edinburgh EH4 2XU, Midlothian, Scotland
机构:
Univ Henri Poincare 1, Dept Hepatogastroenterol, Univ Hosp Nancy, Inserm U954, F-54511 Vandoeuvre Les Nancy, FranceUniv Henri Poincare 1, Dept Hepatogastroenterol, Univ Hosp Nancy, Inserm U954, F-54511 Vandoeuvre Les Nancy, France
Billioud, Vincent
;
Sandborn, William J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Div Gastroenterol, La Jolla, CA 92093 USAUniv Henri Poincare 1, Dept Hepatogastroenterol, Univ Hosp Nancy, Inserm U954, F-54511 Vandoeuvre Les Nancy, France
Sandborn, William J.
;
Peyrin-Biroulet, Laurent
论文数: 0引用数: 0
h-index: 0
机构:
Univ Henri Poincare 1, Dept Hepatogastroenterol, Univ Hosp Nancy, Inserm U954, F-54511 Vandoeuvre Les Nancy, FranceUniv Henri Poincare 1, Dept Hepatogastroenterol, Univ Hosp Nancy, Inserm U954, F-54511 Vandoeuvre Les Nancy, France