Transport and recognition of aminopeptidase-resistant cellobiose-coupled tyrosylglycylglycine by intestinal Na+/glucose cotransporter (SGLT1):: Recognition of sugar conjugates by SGLT1 is much less restricted than transport

被引:0
作者
Mizuma, T
Sakai, N
Hagi, K
Awazu, S
机构
[1] Tokyo Univ Pharm & Life Sci, Dept Biopharmaceut, Tokyo 1920392, Japan
[2] Tokyo Univ Pharm & Life Sci, Drug Rat Res Ctr, Sch Pharm, Tokyo 1920392, Japan
关键词
sodium ion/glucose cotransporter; SGLT1; sugar conjugate; transport; recognition;
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Transport and recognition of aminopeptidase-resistant cellobiose-coupled tyrosylglycylglycine (CcpTGG) by intestinal Na+/glucose cotransporter (SGLT1) was examined in rat small intestine. Inhibitory effect of phloridzin (SGLT1 inhibitor) on the CcpTGG transport was extremely low: Concentration dependence of the CcpTGG transport was observed, but the primary component of transport was passive diffusion. However, CcpTGG significantly inhibited SGLT1-mediated transport, indicating its recognition by SGLT1. Other glucose-conjugates also inhibited SGLT1-mediated transport. These results indicate that recognition of sugar conjugates by SGLT1 is much less restricted than transport, and that it should be relatively easier to design SGLT1 inhibitors than SGLT1-transportable sugar conjugates.
引用
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页码:876 / 879
页数:4
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