C-reactive protein response patterns after antibiotic treatment among children with scalds

Background: Scalds are the most common cause of burns in children, yet there is little information available about the inflammatory response. The aim of the study was to investigate the response to treatment with antibiotics among scalded children by following the C-reactive protein (CRP) concentration, procalcitonin (PCT) concentration, and white blood cell count (WCC) during the first two weeks after injury. Methods: All children with scalds who presented to the Burn Centre during 2010-2016 were included in this retrospective study. All measurements of CRP, PCT, and WCC from the first 14days after injury were recorded, and each patient's maximum values during days 0-2, 3-7, and 8-14 were used for calculations. Multivariable regression for panel data was used to study the inflammatory response after antibiotic treatment. Results: A total of 216 children were included. C-reactive protein was 45mg/L (p<0.001) higher in the group treated with antibiotics, and decreased with 8.8mg/L per day over the studied time in this group, which was more than twice as fast as among the children who were not given antibiotics. Conclusion: The CRP response, among children with minor scalds treated with antibiotics, shows an appreciable rise during the first week of injury that subsided rapidly during the second week. (C) 2017 Elsevier Ltd and ISBI. All rights reserved.